Resting-state brain activity in adult males who stutter.

Although developmental stuttering has been extensively studied with structural and task-based functional magnetic resonance imaging (fMRI), few studies have focused on resting-state brain activity in this disorder. We investigated resting-state brain activity of stuttering subjects by analyzing the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yun Xuan, Chun Meng, Yanhui Yang, Chaozhe Zhu, Liang Wang, Qian Yan, Chunlan Lin, Chunshui Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0c741ece6ff4ca9bba6073f36d213b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d0c741ece6ff4ca9bba6073f36d213b2
record_format	dspace
spelling	oai:doaj.org-article:d0c741ece6ff4ca9bba6073f36d213b22021-11-18T07:29:41ZResting-state brain activity in adult males who stutter.1932-620310.1371/journal.pone.0030570https://doaj.org/article/d0c741ece6ff4ca9bba6073f36d213b22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22276215/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Although developmental stuttering has been extensively studied with structural and task-based functional magnetic resonance imaging (fMRI), few studies have focused on resting-state brain activity in this disorder. We investigated resting-state brain activity of stuttering subjects by analyzing the amplitude of low-frequency fluctuation (ALFF), region of interest (ROI)-based functional connectivity (FC) and independent component analysis (ICA)-based FC. Forty-four adult males with developmental stuttering and 46 age-matched fluent male controls were scanned using resting-state fMRI. ALFF, ROI-based FCs and ICA-based FCs were compared between male stuttering subjects and fluent controls in a voxel-wise manner. Compared with fluent controls, stuttering subjects showed increased ALFF in left brain areas related to speech motor and auditory functions and bilateral prefrontal cortices related to cognitive control. However, stuttering subjects showed decreased ALFF in the left posterior language reception area and bilateral non-speech motor areas. ROI-based FC analysis revealed decreased FC between the posterior language area involved in the perception and decoding of sensory information and anterior brain area involved in the initiation of speech motor function, as well as increased FC within anterior or posterior speech- and language-associated areas and between the prefrontal areas and default-mode network (DMN) in stuttering subjects. ICA showed that stuttering subjects had decreased FC in the DMN and increased FC in the sensorimotor network. Our findings support the concept that stuttering subjects have deficits in multiple functional systems (motor, language, auditory and DMN) and in the connections between them.Yun XuanChun MengYanhui YangChaozhe ZhuLiang WangQian YanChunlan LinChunshui YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30570 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Xuan Chun Meng Yanhui Yang Chaozhe Zhu Liang Wang Qian Yan Chunlan Lin Chunshui Yu Resting-state brain activity in adult males who stutter.
description	Although developmental stuttering has been extensively studied with structural and task-based functional magnetic resonance imaging (fMRI), few studies have focused on resting-state brain activity in this disorder. We investigated resting-state brain activity of stuttering subjects by analyzing the amplitude of low-frequency fluctuation (ALFF), region of interest (ROI)-based functional connectivity (FC) and independent component analysis (ICA)-based FC. Forty-four adult males with developmental stuttering and 46 age-matched fluent male controls were scanned using resting-state fMRI. ALFF, ROI-based FCs and ICA-based FCs were compared between male stuttering subjects and fluent controls in a voxel-wise manner. Compared with fluent controls, stuttering subjects showed increased ALFF in left brain areas related to speech motor and auditory functions and bilateral prefrontal cortices related to cognitive control. However, stuttering subjects showed decreased ALFF in the left posterior language reception area and bilateral non-speech motor areas. ROI-based FC analysis revealed decreased FC between the posterior language area involved in the perception and decoding of sensory information and anterior brain area involved in the initiation of speech motor function, as well as increased FC within anterior or posterior speech- and language-associated areas and between the prefrontal areas and default-mode network (DMN) in stuttering subjects. ICA showed that stuttering subjects had decreased FC in the DMN and increased FC in the sensorimotor network. Our findings support the concept that stuttering subjects have deficits in multiple functional systems (motor, language, auditory and DMN) and in the connections between them.
format	article
author	Yun Xuan Chun Meng Yanhui Yang Chaozhe Zhu Liang Wang Qian Yan Chunlan Lin Chunshui Yu
author_facet	Yun Xuan Chun Meng Yanhui Yang Chaozhe Zhu Liang Wang Qian Yan Chunlan Lin Chunshui Yu
author_sort	Yun Xuan
title	Resting-state brain activity in adult males who stutter.
title_short	Resting-state brain activity in adult males who stutter.
title_full	Resting-state brain activity in adult males who stutter.
title_fullStr	Resting-state brain activity in adult males who stutter.
title_full_unstemmed	Resting-state brain activity in adult males who stutter.
title_sort	resting-state brain activity in adult males who stutter.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/d0c741ece6ff4ca9bba6073f36d213b2
work_keys_str_mv	AT yunxuan restingstatebrainactivityinadultmaleswhostutter AT chunmeng restingstatebrainactivityinadultmaleswhostutter AT yanhuiyang restingstatebrainactivityinadultmaleswhostutter AT chaozhezhu restingstatebrainactivityinadultmaleswhostutter AT liangwang restingstatebrainactivityinadultmaleswhostutter AT qianyan restingstatebrainactivityinadultmaleswhostutter AT chunlanlin restingstatebrainactivityinadultmaleswhostutter AT chunshuiyu restingstatebrainactivityinadultmaleswhostutter
_version_	1718423377811603456

Resting-state brain activity in adult males who stutter.

Ejemplares similares