The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.

The aim of this study is to compare the effects of neuromuscular blockade (NMB) on phase lag entropy (PLE) and the bispectral index (BIS). We recorded the BIS, electromyograph (EMG) activity on a BIS monitor (EMG_BIS), PLE, and EMG activity on a PLE monitor (EMG_PLE) in 40 patients receiving general...

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Autores principales:	Sohee Jin, Hee Jung Baik, Sooyoung Cho, Rack Kyung Chung, Kyoung Ae Kong, Youn Jin Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0c915c3b9184037b16646ca11686aa2
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spelling	oai:doaj.org-article:d0c915c3b9184037b16646ca11686aa22021-12-02T20:14:37ZThe influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.1932-620310.1371/journal.pone.0257467https://doaj.org/article/d0c915c3b9184037b16646ca11686aa22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257467https://doaj.org/toc/1932-6203The aim of this study is to compare the effects of neuromuscular blockade (NMB) on phase lag entropy (PLE) and the bispectral index (BIS). We recorded the BIS, electromyograph (EMG) activity on a BIS monitor (EMG_BIS), PLE, and EMG activity on a PLE monitor (EMG_PLE) in 40 patients receiving general anesthesia. During the awake state, we analyzed the changes in parameters before and 2 min after the eyes were closed. During sedation, we compared the changes in the parameters before and at 4 min after injecting rocuronium (group R) or normal saline (group C) between the two groups. During anesthesia, we compared the changes in parameters before and at 4 min after injecting sugammadex (group B) or normal saline (group D) between the two groups. During the awake state, the BIS, EMG_BIS, and EMG_PLE, but not PLE, decreased significantly with closed eyes. An effect of EMG on the BIS was evident, but not on PLE. During sedation, the BIS decreased with the decrease in EMG_BIS regardless of NMB caused by rocuronium, but NMB decreased PLE, although the degree of the decrease in EMG_PLE after NMB was similar to that after placebo. To determine the effect of NMB on electroencephalograms (EEGs) in groups R and C, we plotted the power spectra before and at 4 min after injecting rocuronium or normal saline. Changes in slow and delta frequency bands were observed at 4 min after injecting rocuronium relative to before injecting rocuronium. There was no effect of EMG on either the BIS or PLE during anesthesia. In conclusion, the effect of electromyograph activity and/or neuromuscular blockade on BIS or PLE depends on the level of consciousness.Sohee JinHee Jung BaikSooyoung ChoRack Kyung ChungKyoung Ae KongYoun Jin KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257467 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sohee Jin Hee Jung Baik Sooyoung Cho Rack Kyung Chung Kyoung Ae Kong Youn Jin Kim The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
description	The aim of this study is to compare the effects of neuromuscular blockade (NMB) on phase lag entropy (PLE) and the bispectral index (BIS). We recorded the BIS, electromyograph (EMG) activity on a BIS monitor (EMG_BIS), PLE, and EMG activity on a PLE monitor (EMG_PLE) in 40 patients receiving general anesthesia. During the awake state, we analyzed the changes in parameters before and 2 min after the eyes were closed. During sedation, we compared the changes in the parameters before and at 4 min after injecting rocuronium (group R) or normal saline (group C) between the two groups. During anesthesia, we compared the changes in parameters before and at 4 min after injecting sugammadex (group B) or normal saline (group D) between the two groups. During the awake state, the BIS, EMG_BIS, and EMG_PLE, but not PLE, decreased significantly with closed eyes. An effect of EMG on the BIS was evident, but not on PLE. During sedation, the BIS decreased with the decrease in EMG_BIS regardless of NMB caused by rocuronium, but NMB decreased PLE, although the degree of the decrease in EMG_PLE after NMB was similar to that after placebo. To determine the effect of NMB on electroencephalograms (EEGs) in groups R and C, we plotted the power spectra before and at 4 min after injecting rocuronium or normal saline. Changes in slow and delta frequency bands were observed at 4 min after injecting rocuronium relative to before injecting rocuronium. There was no effect of EMG on either the BIS or PLE during anesthesia. In conclusion, the effect of electromyograph activity and/or neuromuscular blockade on BIS or PLE depends on the level of consciousness.
format	article
author	Sohee Jin Hee Jung Baik Sooyoung Cho Rack Kyung Chung Kyoung Ae Kong Youn Jin Kim
author_facet	Sohee Jin Hee Jung Baik Sooyoung Cho Rack Kyung Chung Kyoung Ae Kong Youn Jin Kim
author_sort	Sohee Jin
title	The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
title_short	The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
title_full	The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
title_fullStr	The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
title_full_unstemmed	The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.
title_sort	influence of neuromuscular blockade on phase lag entropy and bispectral index: a randomized, controlled trial.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/d0c915c3b9184037b16646ca11686aa2
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The influence of neuromuscular blockade on phase lag entropy and bispectral index: A randomized, controlled trial.

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