Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors

Nan Zhang,1 Ronghui Wang,2 Junnian Hao,1 Yang Yang,1 Hongmi Zou,3 Zhigang Wang1 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 2Department of Ultrasound, Ruijin Hospital, Shanghai Jiao T...

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Autores principales:	Zhang N, Wang R, Hao J, Yang Y, Zou H, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	high-intensity focused ultrasound (HIFU) hollow mesoporous Prussian Blue nanoplatforms hepatocellular carcinoma dual-modality imaging synergistic chemo/thermotherapy theranostics Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d0d2d817283f462eb652a544e91634da
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spelling	oai:doaj.org-article:d0d2d817283f462eb652a544e91634da2021-12-02T02:28:07ZMesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors1178-2013https://doaj.org/article/d0d2d817283f462eb652a544e91634da2017-10-01T00:00:00Zhttps://www.dovepress.com/mesoporous-composite-nanoparticles-for-dual-modality-ultrasoundmagneti-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Nan Zhang,1 Ronghui Wang,2 Junnian Hao,1 Yang Yang,1 Hongmi Zou,3 Zhigang Wang1 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 2Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 3Department of Ophthalmology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Abstract: High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings. Keywords: high-intensity focused ultrasound, HIFU, hollow mesoporous Prussian blue nanoplatforms, hepatocellular carcinoma, dual-modality imaging, synergistic chemo-/thermotherapy, theranosticsZhang NWang RHao JYang YZou HWang ZDove Medical Pressarticlehigh-intensity focused ultrasound (HIFU)hollow mesoporous Prussian Blue nanoplatformshepatocellular carcinomadual-modality imagingsynergistic chemo/thermotherapytheranosticsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7273-7289 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	high-intensity focused ultrasound (HIFU) hollow mesoporous Prussian Blue nanoplatforms hepatocellular carcinoma dual-modality imaging synergistic chemo/thermotherapy theranostics Medicine (General) R5-920
spellingShingle	high-intensity focused ultrasound (HIFU) hollow mesoporous Prussian Blue nanoplatforms hepatocellular carcinoma dual-modality imaging synergistic chemo/thermotherapy theranostics Medicine (General) R5-920 Zhang N Wang R Hao J Yang Y Zou H Wang Z Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
description	Nan Zhang,1 Ronghui Wang,2 Junnian Hao,1 Yang Yang,1 Hongmi Zou,3 Zhigang Wang1 1Chongqing Key Laboratory of Ultrasound Molecular Imaging, Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, 2Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 3Department of Ophthalmology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China Abstract: High-intensity focused ultrasound (HIFU) is a promising and noninvasive treatment for solid tumors, which has been explored for potential clinical applications. However, the clinical applications of HIFU for large and deep tumors such as hepatocellular carcinoma (HCC) are severely limited by unsatisfactory imaging guidance, long therapeutic times, and damage to normal tissue around the tumor due to the high power applied. In this study, we developed doxorubicin/perfluorohexane-encapsulated hollow mesoporous Prussian blue nanoparticles (HMPBs-DOX/PFH) as theranostic agents, which can effectively guide HIFU therapy and enhance its therapeutic effects in combination with chemotherapy, by decreasing the cavitation threshold. We investigated the effects of this agent on ultrasound and magnetic resonance imaging in vitro and in vivo. In addition, we showed a highly efficient HIFU therapeutic effect against HCC tumors, as well as controlled drug release, owing to the phase-transitional performance of the PFH. We therefore conclude that HMPB-DOX/PFH is a safe and efficient nanoplatform, which holds significant promise for cancer theranostics against deep tumors in clinical settings. Keywords: high-intensity focused ultrasound, HIFU, hollow mesoporous Prussian blue nanoplatforms, hepatocellular carcinoma, dual-modality imaging, synergistic chemo-/thermotherapy, theranostics
format	article
author	Zhang N Wang R Hao J Yang Y Zou H Wang Z
author_facet	Zhang N Wang R Hao J Yang Y Zou H Wang Z
author_sort	Zhang N
title	Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
title_short	Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
title_full	Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
title_fullStr	Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
title_full_unstemmed	Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
title_sort	mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d0d2d817283f462eb652a544e91634da
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Mesoporous composite nanoparticles for dual-modality ultrasound/magnetic resonance imaging and synergistic chemo-/thermotherapy against deep tumors

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