A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

Upon ligand binding epidermal growth factor receptor (EGFR) dimerizes and activates its intrinsic kinase to auto-phosphorylate EGFR. Here, the authors engineer and image a FRET-based conformational EGFR indicator which reveals that activation loop phosphorylation induces a catalytically active confo...

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Autores principales:	Martin Baumdick, Márton Gelléri, Chayasith Uttamapinant, Václav Beránek, Jason W. Chin, Philippe I. H. Bastiaens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0d65e78faad450ca2681ad7f1372071
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spelling	oai:doaj.org-article:d0d65e78faad450ca2681ad7f13720712021-12-02T17:32:35ZA conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation10.1038/s41467-018-06299-72041-1723https://doaj.org/article/d0d65e78faad450ca2681ad7f13720712018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06299-7https://doaj.org/toc/2041-1723Upon ligand binding epidermal growth factor receptor (EGFR) dimerizes and activates its intrinsic kinase to auto-phosphorylate EGFR. Here, the authors engineer and image a FRET-based conformational EGFR indicator which reveals that activation loop phosphorylation induces a catalytically active conformation in EGFR monomers.Martin BaumdickMárton GellériChayasith UttamapinantVáclav BeránekJason W. ChinPhilippe I. H. BastiaensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Baumdick Márton Gelléri Chayasith Uttamapinant Václav Beránek Jason W. Chin Philippe I. H. Bastiaens A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
description	Upon ligand binding epidermal growth factor receptor (EGFR) dimerizes and activates its intrinsic kinase to auto-phosphorylate EGFR. Here, the authors engineer and image a FRET-based conformational EGFR indicator which reveals that activation loop phosphorylation induces a catalytically active conformation in EGFR monomers.
format	article
author	Martin Baumdick Márton Gelléri Chayasith Uttamapinant Václav Beránek Jason W. Chin Philippe I. H. Bastiaens
author_facet	Martin Baumdick Márton Gelléri Chayasith Uttamapinant Václav Beránek Jason W. Chin Philippe I. H. Bastiaens
author_sort	Martin Baumdick
title	A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
title_short	A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
title_full	A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
title_fullStr	A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
title_full_unstemmed	A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
title_sort	conformational sensor based on genetic code expansion reveals an autocatalytic component in egfr activation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d0d65e78faad450ca2681ad7f1372071
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A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation

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