A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Abstract It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the I...

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Autores principales:	Elham Karimi, Arman Arab, Masoumeh Rafiee, Reza Amani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0d84490743041c191c9f775168e6674
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spelling	oai:doaj.org-article:d0d84490743041c191c9f775168e66742021-12-02T18:49:36ZA systematic review and meta-analysis of the association between vitamin D and ovarian reserve10.1038/s41598-021-95481-x2045-2322https://doaj.org/article/d0d84490743041c191c9f775168e66742021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95481-xhttps://doaj.org/toc/2045-2322Abstract It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.Elham KarimiArman ArabMasoumeh RafieeReza AmaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elham Karimi Arman Arab Masoumeh Rafiee Reza Amani A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
description	Abstract It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.
format	article
author	Elham Karimi Arman Arab Masoumeh Rafiee Reza Amani
author_facet	Elham Karimi Arman Arab Masoumeh Rafiee Reza Amani
author_sort	Elham Karimi
title	A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
title_short	A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
title_full	A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
title_fullStr	A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
title_full_unstemmed	A systematic review and meta-analysis of the association between vitamin D and ovarian reserve
title_sort	systematic review and meta-analysis of the association between vitamin d and ovarian reserve
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0d84490743041c191c9f775168e6674
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A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

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