Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study

Sileshi Barasa Gelba, Surafel Fikadu, Alemawi Kindie Legesse, Hiwot Wubet, Mihret Alemu Yesuf, Wondwossen Abera, Temesgen Bizuayehu Wube School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, EthiopiaCorrespondence: Temesgen Bizuayehu Wube P.O. Bo...

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Autores principales:	Barasa Gelba S, Fikadu S, Kindie Legesse A, Wubet H, Alemu Yesuf M, Abera W, Bizuayehu Wube T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cd4+ t-cell recovery immunological none-response rate arsi negelle ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d0d86c7e49994a6a8b83f30149878e23
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spelling	oai:doaj.org-article:d0d86c7e49994a6a8b83f30149878e232021-12-02T05:06:41ZAssessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study1179-1373https://doaj.org/article/d0d86c7e49994a6a8b83f30149878e232020-01-01T00:00:00Zhttps://www.dovepress.com/assessment-of-pattern-of-cd4-t-cell-recovery-among-human-immunodeficie-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Sileshi Barasa Gelba, Surafel Fikadu, Alemawi Kindie Legesse, Hiwot Wubet, Mihret Alemu Yesuf, Wondwossen Abera, Temesgen Bizuayehu Wube School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, EthiopiaCorrespondence: Temesgen Bizuayehu Wube P.O. Box: 1560, Hawassa, EthiopiaTel +251-916-60-45-51Email temesgenbizuayehu2@gmail.comBackground: Antiretroviral therapy has resulted in significant reductions in HIV-associated complications by recovering the CD4+ T cell count. Some patients may not be successful in attaining this result, and some may achieve it only after many years of treatment.Objective: This study aimed to assess CD4+ T cell recovery and non-response patterns among HAART experienced HIV-positive patients at the Arsi Negelle health center.Methods: This was a retrospective cross-sectional study conducted among HAART experienced HIV/AIDS patients at Arsi Negelle Health Center from January 01, 2014 to January 06, 2019. Data were documented to a data retrieval form and analyzed with SPSS version 20. Linear regression analysis was used to identify predictors of CD4 count change. A P-value of < 0.05 was considered significant.Results: The total median of CD4+ T cells increased from 257 cells/uL at the baseline to 382 cells/uL after 6 months, then to 591 cells/uL after 60 months of treatment. The non-response rate was 22.1% and 23.8% among the total study participants and children of less than 15 years, respectively. Only baseline CD4+ T cell was associated with a change in CD4+ T cell count.Conclusion: From our study, we can conclude that CD4+ T cell count has recovered in most of the study participants after HAART initiation. The immunological non-response rate of study participants was 22.1% after 12 months on HAART and 7.2% at the end of the study.Keywords: CD4+ T-cell recovery, immunological non-response rate, Arsi Negelle, EthiopiaBarasa Gelba SFikadu SKindie Legesse AWubet HAlemu Yesuf MAbera WBizuayehu Wube TDove Medical Pressarticlecd4+ t-cell recoveryimmunological none-response ratearsi negelleethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 69-77 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cd4+ t-cell recovery immunological none-response rate arsi negelle ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	cd4+ t-cell recovery immunological none-response rate arsi negelle ethiopia Immunologic diseases. Allergy RC581-607 Barasa Gelba S Fikadu S Kindie Legesse A Wubet H Alemu Yesuf M Abera W Bizuayehu Wube T Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
description	Sileshi Barasa Gelba, Surafel Fikadu, Alemawi Kindie Legesse, Hiwot Wubet, Mihret Alemu Yesuf, Wondwossen Abera, Temesgen Bizuayehu Wube School of Medical Laboratory Science, College of Medicine and Health Sciences, Hawassa University, Hawassa, EthiopiaCorrespondence: Temesgen Bizuayehu Wube P.O. Box: 1560, Hawassa, EthiopiaTel +251-916-60-45-51Email temesgenbizuayehu2@gmail.comBackground: Antiretroviral therapy has resulted in significant reductions in HIV-associated complications by recovering the CD4+ T cell count. Some patients may not be successful in attaining this result, and some may achieve it only after many years of treatment.Objective: This study aimed to assess CD4+ T cell recovery and non-response patterns among HAART experienced HIV-positive patients at the Arsi Negelle health center.Methods: This was a retrospective cross-sectional study conducted among HAART experienced HIV/AIDS patients at Arsi Negelle Health Center from January 01, 2014 to January 06, 2019. Data were documented to a data retrieval form and analyzed with SPSS version 20. Linear regression analysis was used to identify predictors of CD4 count change. A P-value of < 0.05 was considered significant.Results: The total median of CD4+ T cells increased from 257 cells/uL at the baseline to 382 cells/uL after 6 months, then to 591 cells/uL after 60 months of treatment. The non-response rate was 22.1% and 23.8% among the total study participants and children of less than 15 years, respectively. Only baseline CD4+ T cell was associated with a change in CD4+ T cell count.Conclusion: From our study, we can conclude that CD4+ T cell count has recovered in most of the study participants after HAART initiation. The immunological non-response rate of study participants was 22.1% after 12 months on HAART and 7.2% at the end of the study.Keywords: CD4+ T-cell recovery, immunological non-response rate, Arsi Negelle, Ethiopia
format	article
author	Barasa Gelba S Fikadu S Kindie Legesse A Wubet H Alemu Yesuf M Abera W Bizuayehu Wube T
author_facet	Barasa Gelba S Fikadu S Kindie Legesse A Wubet H Alemu Yesuf M Abera W Bizuayehu Wube T
author_sort	Barasa Gelba S
title	Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
title_short	Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
title_full	Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
title_fullStr	Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
title_full_unstemmed	Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study
title_sort	assessment of pattern of cd4+ t-cell recovery among human immunodeficiency virus patients after initiation of highly active antiretroviral therapy at arsi negelle health center, ethiopia: a retrospective cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d0d86c7e49994a6a8b83f30149878e23
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Assessment of Pattern of CD4+ T-Cell Recovery Among Human Immunodeficiency Virus Patients After Initiation of Highly Active Antiretroviral Therapy at Arsi Negelle Health Center, Ethiopia: A Retrospective Cross-Sectional Study

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