3D Breast Tumor Models for Radiobiology Applications

Breast cancer is a leading cause of cancer-associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two-d...

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Autores principales:	Akhilandeshwari Ravichandran, Julien Clegg, Mark N. Adams, Madison Hampson, Andrew Fielding, Laura J. Bray
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D radiobiology in vitro breast cancer models radiation therapy radiosensitizers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d0da56dc645644418bab42efe8dd0f27
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spelling	oai:doaj.org-article:d0da56dc645644418bab42efe8dd0f272021-11-25T17:03:04Z3D Breast Tumor Models for Radiobiology Applications10.3390/cancers132257142072-6694https://doaj.org/article/d0da56dc645644418bab42efe8dd0f272021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5714https://doaj.org/toc/2072-6694Breast cancer is a leading cause of cancer-associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two-dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three-dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre-clinical 3D models offer in improving our understanding of this treatment modality.Akhilandeshwari RavichandranJulien CleggMark N. AdamsMadison HampsonAndrew FieldingLaura J. BrayMDPI AGarticle3D radiobiologyin vitro breast cancer modelsradiation therapyradiosensitizersNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5714, p 5714 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D radiobiology in vitro breast cancer models radiation therapy radiosensitizers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	3D radiobiology in vitro breast cancer models radiation therapy radiosensitizers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Akhilandeshwari Ravichandran Julien Clegg Mark N. Adams Madison Hampson Andrew Fielding Laura J. Bray 3D Breast Tumor Models for Radiobiology Applications
description	Breast cancer is a leading cause of cancer-associated death in women. The clinical management of breast cancers is normally carried out using a combination of chemotherapy, surgery and radiation therapy. The majority of research investigating breast cancer therapy until now has mainly utilized two-dimensional (2D) in vitro cultures or murine models of disease. However, there has been significant uptake of three-dimensional (3D) in vitro models by cancer researchers over the past decade, highlighting a complimentary model for studies of radiotherapy, especially in conjunction with chemotherapy. In this review, we underline the effects of radiation therapy on normal and malignant breast cells and tissues, and explore the emerging opportunities that pre-clinical 3D models offer in improving our understanding of this treatment modality.
format	article
author	Akhilandeshwari Ravichandran Julien Clegg Mark N. Adams Madison Hampson Andrew Fielding Laura J. Bray
author_facet	Akhilandeshwari Ravichandran Julien Clegg Mark N. Adams Madison Hampson Andrew Fielding Laura J. Bray
author_sort	Akhilandeshwari Ravichandran
title	3D Breast Tumor Models for Radiobiology Applications
title_short	3D Breast Tumor Models for Radiobiology Applications
title_full	3D Breast Tumor Models for Radiobiology Applications
title_fullStr	3D Breast Tumor Models for Radiobiology Applications
title_full_unstemmed	3D Breast Tumor Models for Radiobiology Applications
title_sort	3d breast tumor models for radiobiology applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0da56dc645644418bab42efe8dd0f27
work_keys_str_mv	AT akhilandeshwariravichandran 3dbreasttumormodelsforradiobiologyapplications AT julienclegg 3dbreasttumormodelsforradiobiologyapplications AT marknadams 3dbreasttumormodelsforradiobiologyapplications AT madisonhampson 3dbreasttumormodelsforradiobiologyapplications AT andrewfielding 3dbreasttumormodelsforradiobiologyapplications AT laurajbray 3dbreasttumormodelsforradiobiologyapplications
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3D Breast Tumor Models for Radiobiology Applications

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