Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors

Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors

Abstract Small subtype of the gastrointestinal stromal tumor (micro-GIST, MG) is usually asymptomatic and is frequently found incidentally in association with gastric adenocarcinoma (GAC). The background of this coincidence is still an open question. This study comprehensively characterized nine MGs...

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Autores principales: Éva Kocsmár, Ildikó Kocsmár, Luca Szalai, Gábor Lendvai, Attila Szijártó, Zsuzsa Schaff, András Kiss, Ilona Kovalszky, Gergő Papp, Gábor Lotz
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Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d0db54f403ef432f89705bcb5c76283e
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spelling oai:doaj.org-article:d0db54f403ef432f89705bcb5c76283e2021-12-02T11:57:58ZCross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors10.1038/s41598-020-78232-22045-2322https://doaj.org/article/d0db54f403ef432f89705bcb5c76283e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78232-2https://doaj.org/toc/2045-2322Abstract Small subtype of the gastrointestinal stromal tumor (micro-GIST, MG) is usually asymptomatic and is frequently found incidentally in association with gastric adenocarcinoma (GAC). The background of this coincidence is still an open question. This study comprehensively characterized nine MGs and GACs present in the same surgical specimen by cross-testing the markers of the major pathogenetic pathways of both tumor types. All of the MGs were immunohistochemically positive for CD117/KIT, CD34, and DOG1. DOG1 was also detected in four GACs. Four MGs carried mutations in c-KIT (exons 9, 11, and 13) and two cases in PDGFRα (exon 18). None of the GACs carried activating mutations in c-KIT or PDGFRα. MMR immunopanel identified one GAC as microsatellite unstable tumor. No EBV-positive tumor was found. According to the TCGA molecular classification, one GAC was categorized in the MSI subgroup, three GACs in the genomically stable subgroup, and the rest into the chromosomal instability subgroup. Although a common carcinogenic effect cannot be ruled out, our data suggest a distinct molecular background in the evolvement of the synchronous MGs and GACs. The presence of a MG in gastric resection specimens may be indicative of the development of synchronous malignant tumors in or outside the stomach.Éva KocsmárIldikó KocsmárLuca SzalaiGábor LendvaiAttila SzijártóZsuzsa SchaffAndrás KissIlona KovalszkyGergő PappGábor LotzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Éva Kocsmár
Ildikó Kocsmár
Luca Szalai
Gábor Lendvai
Attila Szijártó
Zsuzsa Schaff
András Kiss
Ilona Kovalszky
Gergő Papp
Gábor Lotz
Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
description Abstract Small subtype of the gastrointestinal stromal tumor (micro-GIST, MG) is usually asymptomatic and is frequently found incidentally in association with gastric adenocarcinoma (GAC). The background of this coincidence is still an open question. This study comprehensively characterized nine MGs and GACs present in the same surgical specimen by cross-testing the markers of the major pathogenetic pathways of both tumor types. All of the MGs were immunohistochemically positive for CD117/KIT, CD34, and DOG1. DOG1 was also detected in four GACs. Four MGs carried mutations in c-KIT (exons 9, 11, and 13) and two cases in PDGFRα (exon 18). None of the GACs carried activating mutations in c-KIT or PDGFRα. MMR immunopanel identified one GAC as microsatellite unstable tumor. No EBV-positive tumor was found. According to the TCGA molecular classification, one GAC was categorized in the MSI subgroup, three GACs in the genomically stable subgroup, and the rest into the chromosomal instability subgroup. Although a common carcinogenic effect cannot be ruled out, our data suggest a distinct molecular background in the evolvement of the synchronous MGs and GACs. The presence of a MG in gastric resection specimens may be indicative of the development of synchronous malignant tumors in or outside the stomach.
format article
author Éva Kocsmár
Ildikó Kocsmár
Luca Szalai
Gábor Lendvai
Attila Szijártó
Zsuzsa Schaff
András Kiss
Ilona Kovalszky
Gergő Papp
Gábor Lotz
author_facet Éva Kocsmár
Ildikó Kocsmár
Luca Szalai
Gábor Lendvai
Attila Szijártó
Zsuzsa Schaff
András Kiss
Ilona Kovalszky
Gergő Papp
Gábor Lotz
author_sort Éva Kocsmár
title Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
title_short Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
title_full Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
title_fullStr Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
title_full_unstemmed Cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
title_sort cross-testing of major molecular markers indicates distinct pathways of tumorigenesis in gastric adenocarcinomas and synchronous gastrointestinal stromal tumors
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d0db54f403ef432f89705bcb5c76283e
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