Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels ca...

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Autores principales: Fanlei Hu, Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen, Wei Zhang, Yan Du, Ping Wang, Xi Zheng, Xiangyu Fang, Xin Li, Jing Song, Yang Xie, Fei Huang, Jimeng Xue, Mingxin Bai, Yuan Jia, Xu Liu, Limin Ren, Xiaoying Zhang, Jianping Guo, Hudan Pan, Yin Su, Huanfa Yi, Hua Ye, Daming Zuo, Juan Li, Huaxiang Wu, Yongfu Wang, Ru Li, Liang Liu, Xiang-Yang Wang, Zhanguo Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/d0dc96c37f214a199f16725f1f4d38ba
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Sumario:Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.

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