Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study

Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels ca...

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Autores principales: Fanlei Hu, Xiang Jiang, Chunqing Guo, Yingni Li, Shixian Chen, Wei Zhang, Yan Du, Ping Wang, Xi Zheng, Xiangyu Fang, Xin Li, Jing Song, Yang Xie, Fei Huang, Jimeng Xue, Mingxin Bai, Yuan Jia, Xu Liu, Limin Ren, Xiaoying Zhang, Jianping Guo, Hudan Pan, Yin Su, Huanfa Yi, Hua Ye, Daming Zuo, Juan Li, Huaxiang Wu, Yongfu Wang, Ru Li, Liang Liu, Xiang-Yang Wang, Zhanguo Li
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d0dc96c37f214a199f16725f1f4d38ba
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spelling oai:doaj.org-article:d0dc96c37f214a199f16725f1f4d38ba2021-12-02T17:33:12ZScavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study10.1038/s41467-020-15700-32041-1723https://doaj.org/article/d0dc96c37f214a199f16725f1f4d38ba2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15700-3https://doaj.org/toc/2041-1723Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.Fanlei HuXiang JiangChunqing GuoYingni LiShixian ChenWei ZhangYan DuPing WangXi ZhengXiangyu FangXin LiJing SongYang XieFei HuangJimeng XueMingxin BaiYuan JiaXu LiuLimin RenXiaoying ZhangJianping GuoHudan PanYin SuHuanfa YiHua YeDaming ZuoJuan LiHuaxiang WuYongfu WangRu LiLiang LiuXiang-Yang WangZhanguo LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fanlei Hu
Xiang Jiang
Chunqing Guo
Yingni Li
Shixian Chen
Wei Zhang
Yan Du
Ping Wang
Xi Zheng
Xiangyu Fang
Xin Li
Jing Song
Yang Xie
Fei Huang
Jimeng Xue
Mingxin Bai
Yuan Jia
Xu Liu
Limin Ren
Xiaoying Zhang
Jianping Guo
Hudan Pan
Yin Su
Huanfa Yi
Hua Ye
Daming Zuo
Juan Li
Huaxiang Wu
Yongfu Wang
Ru Li
Liang Liu
Xiang-Yang Wang
Zhanguo Li
Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
description Scavenger receptor-A (SR-A) is mostly expressed by myeloid cells and has been attributed a variety of biological functions. Here the authors assess SR-A as a biomarker for diagnosis of rheumatoid arthritis (RA) using large-scale training and validation cohorts and show that modulating SR-A levels can alter progression of collagen-induced arthritis in mice.
format article
author Fanlei Hu
Xiang Jiang
Chunqing Guo
Yingni Li
Shixian Chen
Wei Zhang
Yan Du
Ping Wang
Xi Zheng
Xiangyu Fang
Xin Li
Jing Song
Yang Xie
Fei Huang
Jimeng Xue
Mingxin Bai
Yuan Jia
Xu Liu
Limin Ren
Xiaoying Zhang
Jianping Guo
Hudan Pan
Yin Su
Huanfa Yi
Hua Ye
Daming Zuo
Juan Li
Huaxiang Wu
Yongfu Wang
Ru Li
Liang Liu
Xiang-Yang Wang
Zhanguo Li
author_facet Fanlei Hu
Xiang Jiang
Chunqing Guo
Yingni Li
Shixian Chen
Wei Zhang
Yan Du
Ping Wang
Xi Zheng
Xiangyu Fang
Xin Li
Jing Song
Yang Xie
Fei Huang
Jimeng Xue
Mingxin Bai
Yuan Jia
Xu Liu
Limin Ren
Xiaoying Zhang
Jianping Guo
Hudan Pan
Yin Su
Huanfa Yi
Hua Ye
Daming Zuo
Juan Li
Huaxiang Wu
Yongfu Wang
Ru Li
Liang Liu
Xiang-Yang Wang
Zhanguo Li
author_sort Fanlei Hu
title Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
title_short Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
title_full Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
title_fullStr Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
title_full_unstemmed Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study
title_sort scavenger receptor-a is a biomarker and effector of rheumatoid arthritis: a large-scale multicenter study
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d0dc96c37f214a199f16725f1f4d38ba
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