Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study

Abstract Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding mul...

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Autores principales:	Valerie C. Brandt, Ann-Kathrin Stock, Alexander Münchau, Christian Beste
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d0dfac8f54064ab39a7ffe6dc68a118e
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spelling	oai:doaj.org-article:d0dfac8f54064ab39a7ffe6dc68a118e2021-12-02T12:32:44ZEvidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study10.1038/s41598-017-08158-92045-2322https://doaj.org/article/d0dfac8f54064ab39a7ffe6dc68a118e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08158-9https://doaj.org/toc/2045-2322Abstract Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.Valerie C. BrandtAnn-Kathrin StockAlexander MünchauChristian BesteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valerie C. Brandt Ann-Kathrin Stock Alexander Münchau Christian Beste Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
description	Abstract Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.
format	article
author	Valerie C. Brandt Ann-Kathrin Stock Alexander Münchau Christian Beste
author_facet	Valerie C. Brandt Ann-Kathrin Stock Alexander Münchau Christian Beste
author_sort	Valerie C. Brandt
title	Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_short	Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_full	Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_fullStr	Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_full_unstemmed	Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_sort	evidence for enhanced multi-component behaviour in tourette syndrome – an eeg study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d0dfac8f54064ab39a7ffe6dc68a118e
work_keys_str_mv	AT valeriecbrandt evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy AT annkathrinstock evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy AT alexandermunchau evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy AT christianbeste evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy
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Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study

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