A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.

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Autores principales:	Guohao Wang, Lisi Xie, Bei Li, Wei Sang, Jie Yan, Jie Li, Hao Tian, Wenxi Li, Zhan Zhang, Ye Tian, Yunlu Dai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0e25276be7f4139860cffdfc046439d
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spelling	oai:doaj.org-article:d0e25276be7f4139860cffdfc046439d2021-12-02T17:37:13ZA nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis10.1038/s41467-021-25990-w2041-1723https://doaj.org/article/d0e25276be7f4139860cffdfc046439d2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25990-whttps://doaj.org/toc/2041-1723PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.Guohao WangLisi XieBei LiWei SangJie YanJie LiHao TianWenxi LiZhan ZhangYe TianYunlu DaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
description	PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.
format	article
author	Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai
author_facet	Guohao Wang Lisi Xie Bei Li Wei Sang Jie Yan Jie Li Hao Tian Wenxi Li Zhan Zhang Ye Tian Yunlu Dai
author_sort	Guohao Wang
title	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_short	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_fullStr	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_full_unstemmed	A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
title_sort	nanounit strategy reverses immune suppression of exosomal pd-l1 and is associated with enhanced ferroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0e25276be7f4139860cffdfc046439d
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A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis

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