A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis
PD-L1 is frequently expressed on the surface of cancer cells and can be excreted from cancer cells in exosomes. Here, the authors generate a nanotherapy that combines an inhibitor of exosome production and an inducer of ferroptosis, enhancing the response to immune checkpoint blockade therapy.
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Autores principales: | Guohao Wang, Lisi Xie, Bei Li, Wei Sang, Jie Yan, Jie Li, Hao Tian, Wenxi Li, Zhan Zhang, Ye Tian, Yunlu Dai |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/d0e25276be7f4139860cffdfc046439d |
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