Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA

Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular basis for the interaction and cooperativity between a r...

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Autores principales:	Clément Madru, Ghislaine Henneke, Pierre Raia, Inès Hugonneau-Beaufet, Gérard Pehau-Arnaudet, Patrick England, Erik Lindahl, Marc Delarue, Marta Carroni, Ludovic Sauguet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0e3b6dc33ce4f07adff0554f5e474a0
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spelling	oai:doaj.org-article:d0e3b6dc33ce4f07adff0554f5e474a02021-12-02T14:41:26ZStructural basis for the increased processivity of D-family DNA polymerases in complex with PCNA10.1038/s41467-020-15392-92041-1723https://doaj.org/article/d0e3b6dc33ce4f07adff0554f5e474a02020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15392-9https://doaj.org/toc/2041-1723Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular basis for the interaction and cooperativity between a replicative DNAP and PCNA.Clément MadruGhislaine HennekePierre RaiaInès Hugonneau-BeaufetGérard Pehau-ArnaudetPatrick EnglandErik LindahlMarc DelarueMarta CarroniLudovic SauguetNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clément Madru Ghislaine Henneke Pierre Raia Inès Hugonneau-Beaufet Gérard Pehau-Arnaudet Patrick England Erik Lindahl Marc Delarue Marta Carroni Ludovic Sauguet Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
description	Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular basis for the interaction and cooperativity between a replicative DNAP and PCNA.
format	article
author	Clément Madru Ghislaine Henneke Pierre Raia Inès Hugonneau-Beaufet Gérard Pehau-Arnaudet Patrick England Erik Lindahl Marc Delarue Marta Carroni Ludovic Sauguet
author_facet	Clément Madru Ghislaine Henneke Pierre Raia Inès Hugonneau-Beaufet Gérard Pehau-Arnaudet Patrick England Erik Lindahl Marc Delarue Marta Carroni Ludovic Sauguet
author_sort	Clément Madru
title	Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
title_short	Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
title_full	Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
title_fullStr	Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
title_full_unstemmed	Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA
title_sort	structural basis for the increased processivity of d-family dna polymerases in complex with pcna
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d0e3b6dc33ce4f07adff0554f5e474a0
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Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA

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