Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview

Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present a...

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Autores principales:	Giuseppe Gullo, Andrea Etrusco, Gaspare Cucinella, Antonino Perino, Vito Chiantera, Antonio Simone Laganà, Rossella Tomaiuolo, Amerigo Vitagliano, Pierluigi Giampaolino, Marco Noventa, Alessandra Andrisani, Giovanni Buzzaccarini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endometrial cancer fertility sparing fertility preservation ART infertility progestin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d0e857953d5f41569a4402df1482624f
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spelling	oai:doaj.org-article:d0e857953d5f41569a4402df1482624f2021-11-11T17:15:43ZFertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview10.3390/ijms2221118251422-00671661-6596https://doaj.org/article/d0e857953d5f41569a4402df1482624f2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11825https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.Giuseppe GulloAndrea EtruscoGaspare CucinellaAntonino PerinoVito ChianteraAntonio Simone LaganàRossella TomaiuoloAmerigo VitaglianoPierluigi GiampaolinoMarco NoventaAlessandra AndrisaniGiovanni BuzzaccariniMDPI AGarticleendometrial cancerfertility sparingfertility preservationARTinfertilityprogestinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11825, p 11825 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometrial cancer fertility sparing fertility preservation ART infertility progestin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endometrial cancer fertility sparing fertility preservation ART infertility progestin Biology (General) QH301-705.5 Chemistry QD1-999 Giuseppe Gullo Andrea Etrusco Gaspare Cucinella Antonino Perino Vito Chiantera Antonio Simone Laganà Rossella Tomaiuolo Amerigo Vitagliano Pierluigi Giampaolino Marco Noventa Alessandra Andrisani Giovanni Buzzaccarini Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
description	Endometrial cancer (EC) is a deleterious condition which strongly affects a woman’s quality of life. Although aggressive interventions should be considered to treat high-grade EC, a conservative approach should be taken into consideration for women wishing to conceive. In this scenario, we present an overview about the EC fertility-sparing approach state of art. Type I EC at low stage is the only histological type which can be addressed with a fertility-sparing approach. Moreover, no myometrium and/or adnexal invasion should be seen, and lymph-vascular space should not be involved. Regarding the pharmaceutical target, progestins, in particular medroxyprogesterone acetate (MPA) or megestrol acetate (MA), are the most employed agent in conservative treatment of early-stage EC. The metformin usage and hysteroscopic assessment is still under debate, despite promising results. Particularly strict and imperious attention should be given to the follow-up and psychological wellbeing of women, especially because of the double detrimental impairment: both EC and EC-related infertility consequences.
format	article
author	Giuseppe Gullo Andrea Etrusco Gaspare Cucinella Antonino Perino Vito Chiantera Antonio Simone Laganà Rossella Tomaiuolo Amerigo Vitagliano Pierluigi Giampaolino Marco Noventa Alessandra Andrisani Giovanni Buzzaccarini
author_facet	Giuseppe Gullo Andrea Etrusco Gaspare Cucinella Antonino Perino Vito Chiantera Antonio Simone Laganà Rossella Tomaiuolo Amerigo Vitagliano Pierluigi Giampaolino Marco Noventa Alessandra Andrisani Giovanni Buzzaccarini
author_sort	Giuseppe Gullo
title	Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_short	Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_full	Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_fullStr	Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_full_unstemmed	Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview
title_sort	fertility-sparing approach in women affected by stage i and low-grade endometrial carcinoma: an updated overview
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0e857953d5f41569a4402df1482624f
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Fertility-Sparing Approach in Women Affected by Stage I and Low-Grade Endometrial Carcinoma: An Updated Overview

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