The Relevance of G-Quadruplexes for DNA Repair

DNA molecules can adopt a variety of alternative structures. Among these structures are G-quadruplex DNA structures (G4s), which support cellular function by affecting transcription, translation, and telomere maintenance. These structures can also induce genome instability by stalling replication, i...

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Autores principales:	Rebecca Linke, Michaela Limmer, Stefan A. Juranek, Annkristin Heine, Katrin Paeschke
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	G-quadruplex genome instability homologous recombination non-homologous end joining nucleotide excision repair translesion synthesis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d0ed49a2557446328a829647734f73d3
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spelling	oai:doaj.org-article:d0ed49a2557446328a829647734f73d32021-11-25T17:58:12ZThe Relevance of G-Quadruplexes for DNA Repair10.3390/ijms2222125991422-00671661-6596https://doaj.org/article/d0ed49a2557446328a829647734f73d32021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12599https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067DNA molecules can adopt a variety of alternative structures. Among these structures are G-quadruplex DNA structures (G4s), which support cellular function by affecting transcription, translation, and telomere maintenance. These structures can also induce genome instability by stalling replication, increasing DNA damage, and recombination events. G-quadruplex-driven genome instability is connected to tumorigenesis and other genetic disorders. In recent years, the connection between genome stability, DNA repair and G4 formation was further underlined by the identification of multiple DNA repair proteins and ligands which bind and stabilize said G4 structures to block specific DNA repair pathways. The relevance of G4s for different DNA repair pathways is complex and depends on the repair pathway itself. G4 structures can induce DNA damage and block efficient DNA repair, but they can also support the activity and function of certain repair pathways. In this review, we highlight the roles and consequences of G4 DNA structures for DNA repair initiation, processing, and the efficiency of various DNA repair pathways.Rebecca LinkeMichaela LimmerStefan A. JuranekAnnkristin HeineKatrin PaeschkeMDPI AGarticleG-quadruplexgenome instabilityhomologous recombinationnon-homologous end joiningnucleotide excision repairtranslesion synthesisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12599, p 12599 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	G-quadruplex genome instability homologous recombination non-homologous end joining nucleotide excision repair translesion synthesis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	G-quadruplex genome instability homologous recombination non-homologous end joining nucleotide excision repair translesion synthesis Biology (General) QH301-705.5 Chemistry QD1-999 Rebecca Linke Michaela Limmer Stefan A. Juranek Annkristin Heine Katrin Paeschke The Relevance of G-Quadruplexes for DNA Repair
description	DNA molecules can adopt a variety of alternative structures. Among these structures are G-quadruplex DNA structures (G4s), which support cellular function by affecting transcription, translation, and telomere maintenance. These structures can also induce genome instability by stalling replication, increasing DNA damage, and recombination events. G-quadruplex-driven genome instability is connected to tumorigenesis and other genetic disorders. In recent years, the connection between genome stability, DNA repair and G4 formation was further underlined by the identification of multiple DNA repair proteins and ligands which bind and stabilize said G4 structures to block specific DNA repair pathways. The relevance of G4s for different DNA repair pathways is complex and depends on the repair pathway itself. G4 structures can induce DNA damage and block efficient DNA repair, but they can also support the activity and function of certain repair pathways. In this review, we highlight the roles and consequences of G4 DNA structures for DNA repair initiation, processing, and the efficiency of various DNA repair pathways.
format	article
author	Rebecca Linke Michaela Limmer Stefan A. Juranek Annkristin Heine Katrin Paeschke
author_facet	Rebecca Linke Michaela Limmer Stefan A. Juranek Annkristin Heine Katrin Paeschke
author_sort	Rebecca Linke
title	The Relevance of G-Quadruplexes for DNA Repair
title_short	The Relevance of G-Quadruplexes for DNA Repair
title_full	The Relevance of G-Quadruplexes for DNA Repair
title_fullStr	The Relevance of G-Quadruplexes for DNA Repair
title_full_unstemmed	The Relevance of G-Quadruplexes for DNA Repair
title_sort	relevance of g-quadruplexes for dna repair
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0ed49a2557446328a829647734f73d3
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The Relevance of G-Quadruplexes for DNA Repair

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