DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome
Critical mutations of mitochondrial DNA (mtDNA) generally lead to maternally inheritable diseases that affect multiple organs and systems; however, it was difficult to alter mtDNA in mammalian cells to intervene in or cure mitochondrial disorders. Recently, the discovery of DddA-derived cytosine bas...
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Auteurs principaux: | Jiayin Guo, Xiaoxu Chen, Zhiwei Liu, Haifeng Sun, Yu Zhou, Yichen Dai, Yu'e Ma, Lei He, Xuezhen Qian, Jianying Wang, Jie Zhang, Yichen Zhu, Jun Zhang, Bin Shen, Fei Zhou |
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Format: | article |
Langue: | EN |
Publié: |
Elsevier
2022
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Accès en ligne: | https://doaj.org/article/d0efd2d09726457fb6ad0eba937a0219 |
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