Changes in the blood antioxidant defense of advanced age people

Mariusz Kozakiewicz,1 Maciej Kornatowski,2 Olga Krzywińska,1 Kornelia Kędziora-Kornatowska21Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medicum in Bydgoszcz, Department of Food Chemistry, Bydgoszcz, Poland; 2Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medi...

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Autores principales:	Kozakiewicz M, Kornatowski M, Krzywińska O, Kędziora-Kornatowska K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Aging Antioxidant enzymes Free radicals Oxidative stress Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d0f07525042c4f8ba3817d81af80c11f
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spelling	oai:doaj.org-article:d0f07525042c4f8ba3817d81af80c11f2021-12-02T08:50:43ZChanges in the blood antioxidant defense of advanced age people1178-1998https://doaj.org/article/d0f07525042c4f8ba3817d81af80c11f2019-05-01T00:00:00Zhttps://www.dovepress.com/changes-in-the-blood-antioxidant-defense-of-advanced-age-people-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Mariusz Kozakiewicz,1 Maciej Kornatowski,2 Olga Krzywińska,1 Kornelia Kędziora-Kornatowska21Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medicum in Bydgoszcz, Department of Food Chemistry, Bydgoszcz, Poland; 2Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medicum in Bydgoszcz, Department and Clinic of Geriatrics, Bydgoszcz, PolandIntroduction: Since 1956 there have been numerous scientific articles about free radical theory of aging which both confirm and deny the theory. Due to oxygen metabolism, there are relatively high concentrations of molecular oxygen in human cells, especially in mitochondria. Under normal physiological conditions, a small fraction of oxygen is constantly converted to ROS, such as superoxide radical (O2−•,), H2O2, and related metabolites.Aim of the study: The aim of this work was to show the relation between the activity of main antioxidative enzymes and the age of the examined patients.Materials and methods: The analysis of antioxidant defense was performed on the blood samples from 184 “aged“ individuals aged 65–90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55–59 years.Results: The statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activities and malondialdehyde concentrations were observed.Conclusion: Lower activities of fundamental antioxidant enzymes in the erythrocytes of elderly people, which indicate the impairment of antioxidant defense in the aging organism and the intensity of peroxidative lipid structures, were observed.Keywords: aging, antioxidant enzymes, free radicals, oxidative stressKozakiewicz MKornatowski MKrzywińska OKędziora-Kornatowska KDove Medical PressarticleAgingAntioxidant enzymesFree radicalsOxidative stressGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 763-771 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aging Antioxidant enzymes Free radicals Oxidative stress Geriatrics RC952-954.6
spellingShingle	Aging Antioxidant enzymes Free radicals Oxidative stress Geriatrics RC952-954.6 Kozakiewicz M Kornatowski M Krzywińska O Kędziora-Kornatowska K Changes in the blood antioxidant defense of advanced age people
description	Mariusz Kozakiewicz,1 Maciej Kornatowski,2 Olga Krzywińska,1 Kornelia Kędziora-Kornatowska21Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medicum in Bydgoszcz, Department of Food Chemistry, Bydgoszcz, Poland; 2Nicolaus Copernicus University in Torun Ludwig Rydygier Collegium Medicum in Bydgoszcz, Department and Clinic of Geriatrics, Bydgoszcz, PolandIntroduction: Since 1956 there have been numerous scientific articles about free radical theory of aging which both confirm and deny the theory. Due to oxygen metabolism, there are relatively high concentrations of molecular oxygen in human cells, especially in mitochondria. Under normal physiological conditions, a small fraction of oxygen is constantly converted to ROS, such as superoxide radical (O2−•,), H2O2, and related metabolites.Aim of the study: The aim of this work was to show the relation between the activity of main antioxidative enzymes and the age of the examined patients.Materials and methods: The analysis of antioxidant defense was performed on the blood samples from 184 “aged“ individuals aged 65–90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55–59 years.Results: The statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activities and malondialdehyde concentrations were observed.Conclusion: Lower activities of fundamental antioxidant enzymes in the erythrocytes of elderly people, which indicate the impairment of antioxidant defense in the aging organism and the intensity of peroxidative lipid structures, were observed.Keywords: aging, antioxidant enzymes, free radicals, oxidative stress
format	article
author	Kozakiewicz M Kornatowski M Krzywińska O Kędziora-Kornatowska K
author_facet	Kozakiewicz M Kornatowski M Krzywińska O Kędziora-Kornatowska K
author_sort	Kozakiewicz M
title	Changes in the blood antioxidant defense of advanced age people
title_short	Changes in the blood antioxidant defense of advanced age people
title_full	Changes in the blood antioxidant defense of advanced age people
title_fullStr	Changes in the blood antioxidant defense of advanced age people
title_full_unstemmed	Changes in the blood antioxidant defense of advanced age people
title_sort	changes in the blood antioxidant defense of advanced age people
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d0f07525042c4f8ba3817d81af80c11f
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Changes in the blood antioxidant defense of advanced age people

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