Combination therapy protects macaques against advanced Marburg virus disease

Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protection in non-human primates.

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Autores principales:	Robert W. Cross, Zachary A. Bornholdt, Abhishek N. Prasad, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Dafna M. Abelson, Do H. Kim, William S. Shestowsky, Lioudmila A. Campbell, Elaine Bunyan, Joan B. Geisbert, Karla A. Fenton, Larry Zeitlin, Danielle P. Porter, Thomas W. Geisbert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a8
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spelling	oai:doaj.org-article:d0f0bff00c684416a81ac789aecee0a82021-12-02T16:36:00ZCombination therapy protects macaques against advanced Marburg virus disease10.1038/s41467-021-22132-02041-1723https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22132-0https://doaj.org/toc/2041-1723Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protection in non-human primates.Robert W. CrossZachary A. BornholdtAbhishek N. PrasadViktoriya BorisevichKrystle N. AgansDaniel J. DeerDafna M. AbelsonDo H. KimWilliam S. ShestowskyLioudmila A. CampbellElaine BunyanJoan B. GeisbertKarla A. FentonLarry ZeitlinDanielle P. PorterThomas W. GeisbertNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Robert W. Cross Zachary A. Bornholdt Abhishek N. Prasad Viktoriya Borisevich Krystle N. Agans Daniel J. Deer Dafna M. Abelson Do H. Kim William S. Shestowsky Lioudmila A. Campbell Elaine Bunyan Joan B. Geisbert Karla A. Fenton Larry Zeitlin Danielle P. Porter Thomas W. Geisbert Combination therapy protects macaques against advanced Marburg virus disease
description	Extending the therapeutic window for acute viral infections could save lives. Here, the authors show that combination treatment with a human monoclonal antibody and remdesivir initiated at 6 days post infection with Marburg virus provides 80% protection in non-human primates.
format	article
author	Robert W. Cross Zachary A. Bornholdt Abhishek N. Prasad Viktoriya Borisevich Krystle N. Agans Daniel J. Deer Dafna M. Abelson Do H. Kim William S. Shestowsky Lioudmila A. Campbell Elaine Bunyan Joan B. Geisbert Karla A. Fenton Larry Zeitlin Danielle P. Porter Thomas W. Geisbert
author_facet	Robert W. Cross Zachary A. Bornholdt Abhishek N. Prasad Viktoriya Borisevich Krystle N. Agans Daniel J. Deer Dafna M. Abelson Do H. Kim William S. Shestowsky Lioudmila A. Campbell Elaine Bunyan Joan B. Geisbert Karla A. Fenton Larry Zeitlin Danielle P. Porter Thomas W. Geisbert
author_sort	Robert W. Cross
title	Combination therapy protects macaques against advanced Marburg virus disease
title_short	Combination therapy protects macaques against advanced Marburg virus disease
title_full	Combination therapy protects macaques against advanced Marburg virus disease
title_fullStr	Combination therapy protects macaques against advanced Marburg virus disease
title_full_unstemmed	Combination therapy protects macaques against advanced Marburg virus disease
title_sort	combination therapy protects macaques against advanced marburg virus disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d0f0bff00c684416a81ac789aecee0a8
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Combination therapy protects macaques against advanced Marburg virus disease

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