Nanotechnology-based drug delivery systems and herbal medicines: a review

Nanotechnology-based drug delivery systems and herbal medicines: a review

Bruna Vidal Bonifácio, Patricia Bento da Silva, Matheus Aparecido dos Santos Ramos, Kamila Maria Silveira Negri, Taís Maria Bauab, Marlus Chorilli School of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraqua...

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Autores principales: Bonifácio BV, Silva PB, Ramos MAS, Negri KMS, Bauab TM, Chorilli M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/d0f27ff23c344c54aa4583aba43d2f2f
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spelling oai:doaj.org-article:d0f27ff23c344c54aa4583aba43d2f2f2021-12-02T05:10:55ZNanotechnology-based drug delivery systems and herbal medicines: a review1176-91141178-2013https://doaj.org/article/d0f27ff23c344c54aa4583aba43d2f2f2013-12-01T00:00:00Zhttp://www.dovepress.com/nanotechnology-based-drug-delivery-systems-and-herbal-medicines-a-revi-a15228https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Bruna Vidal Bonifácio, Patricia Bento da Silva, Matheus Aparecido dos Santos Ramos, Kamila Maria Silveira Negri, Taís Maria Bauab, Marlus Chorilli School of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil Abstract: Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines. Keywords: natural products, herbal medicines, nanotechnology, drug delivery systems, biological activityBonifácio BVSilva PBRamos MASNegri KMSBauab TMChorilli MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1-15 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Bonifácio BV
Silva PB
Ramos MAS
Negri KMS
Bauab TM
Chorilli M
Nanotechnology-based drug delivery systems and herbal medicines: a review
description Bruna Vidal Bonifácio, Patricia Bento da Silva, Matheus Aparecido dos Santos Ramos, Kamila Maria Silveira Negri, Taís Maria Bauab, Marlus Chorilli School of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil Abstract: Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines. Keywords: natural products, herbal medicines, nanotechnology, drug delivery systems, biological activity
format article
author Bonifácio BV
Silva PB
Ramos MAS
Negri KMS
Bauab TM
Chorilli M
author_facet Bonifácio BV
Silva PB
Ramos MAS
Negri KMS
Bauab TM
Chorilli M
author_sort Bonifácio BV
title Nanotechnology-based drug delivery systems and herbal medicines: a review
title_short Nanotechnology-based drug delivery systems and herbal medicines: a review
title_full Nanotechnology-based drug delivery systems and herbal medicines: a review
title_fullStr Nanotechnology-based drug delivery systems and herbal medicines: a review
title_full_unstemmed Nanotechnology-based drug delivery systems and herbal medicines: a review
title_sort nanotechnology-based drug delivery systems and herbal medicines: a review
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/d0f27ff23c344c54aa4583aba43d2f2f
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AT silvapb nanotechnologybaseddrugdeliverysystemsandherbalmedicinesareview
AT ramosmas nanotechnologybaseddrugdeliverysystemsandherbalmedicinesareview
AT negrikms nanotechnologybaseddrugdeliverysystemsandherbalmedicinesareview
AT bauabtm nanotechnologybaseddrugdeliverysystemsandherbalmedicinesareview
AT chorillim nanotechnologybaseddrugdeliverysystemsandherbalmedicinesareview
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