Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Here, Ferren et al. isolate Syrian hamster brainstem and lung tissue to establish ex vivo culture systems to study SARS-CoV-2 local viral tropism, immune response and tissue pathology. Further, they provide evidence that these systems can be used for screening of anti-viral compounds.

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Detalles Bibliográficos
Autores principales: Marion Ferren, Valérie Favède, Didier Decimo, Mathieu Iampietro, Nicole A. P. Lieberman, Jean-Luc Weickert, Rodolphe Pelissier, Magalie Mazelier, Olivier Terrier, Anne Moscona, Matteo Porotto, Alexander L. Greninger, Nadia Messaddeq, Branka Horvat, Cyrille Mathieu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/d0f36ce0ff77494588238708b9573bc8
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Descripción
Sumario:Here, Ferren et al. isolate Syrian hamster brainstem and lung tissue to establish ex vivo culture systems to study SARS-CoV-2 local viral tropism, immune response and tissue pathology. Further, they provide evidence that these systems can be used for screening of anti-viral compounds.

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