Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers

Context.Proteins in the saliva are one of the defense mechanism factors that can protect the oral cavity from disease. However, smoking might affect the properties of saliva. Aim: To determine the differences in salivary protein profiles and total concentrations in smokers and non-smokers and their...

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Autores principales:	Endang W. Bachtiar, Destri S. Gusliana, Boy M. Bachtiar
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Smokers Salivary protein DMF-T scores Protein bands Molecular weight SDS-PAGE Medicine R Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/d0f4dfe0cf7844d49280d14cae09f640
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spelling	oai:doaj.org-article:d0f4dfe0cf7844d49280d14cae09f6402021-11-10T04:19:41ZCorrelation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers1013-905210.1016/j.sdentj.2020.09.002https://doaj.org/article/d0f4dfe0cf7844d49280d14cae09f6402021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1013905220307707https://doaj.org/toc/1013-9052Context.Proteins in the saliva are one of the defense mechanism factors that can protect the oral cavity from disease. However, smoking might affect the properties of saliva. Aim: To determine the differences in salivary protein profiles and total concentrations in smokers and non-smokers and their correlation with dental caries severity as indicated by the Decayed, Missing, Filled-Teeth (DMF-T) scores. Methods and material: This cross-sectional study included 25 smokers and 25 non-smokers. The DMF-T scores were recorded. The total salivary protein was measured by the Bradford method, and the profile proteins were determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Results: The average of salivary protein concentration in smokers was lower than that in non-smokers (551.486 µg/mL versus 765.361 µg/mL), but the difference was not statistically significant (P > 0.05). Further correlation analyses showed a negative correlation between the concentration of proteins based on the extent of smoking. A weak negative correlation was found between protein concentration and DMF-T scores (r = −0.239). Dominant salivary protein bands of 11.6 kDa and 54.5 kDa were found in smokers and 27 kDa, 60 kDa, and 94.5 kDa were found in non-smokers. Conclusion: Different protein bands appeared in smokers and non-smokers. There was a weak correlation between protein concentration, DMF-T scores, and the extent of smoking.Endang W. BachtiarDestri S. GuslianaBoy M. BachtiarElsevierarticleSmokersSalivary proteinDMF-T scoresProtein bandsMolecular weightSDS-PAGEMedicineRDentistryRK1-715ENSaudi Dental Journal, Vol 33, Iss 7, Pp 533-537 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Smokers Salivary protein DMF-T scores Protein bands Molecular weight SDS-PAGE Medicine R Dentistry RK1-715
spellingShingle	Smokers Salivary protein DMF-T scores Protein bands Molecular weight SDS-PAGE Medicine R Dentistry RK1-715 Endang W. Bachtiar Destri S. Gusliana Boy M. Bachtiar Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
description	Context.Proteins in the saliva are one of the defense mechanism factors that can protect the oral cavity from disease. However, smoking might affect the properties of saliva. Aim: To determine the differences in salivary protein profiles and total concentrations in smokers and non-smokers and their correlation with dental caries severity as indicated by the Decayed, Missing, Filled-Teeth (DMF-T) scores. Methods and material: This cross-sectional study included 25 smokers and 25 non-smokers. The DMF-T scores were recorded. The total salivary protein was measured by the Bradford method, and the profile proteins were determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Results: The average of salivary protein concentration in smokers was lower than that in non-smokers (551.486 µg/mL versus 765.361 µg/mL), but the difference was not statistically significant (P > 0.05). Further correlation analyses showed a negative correlation between the concentration of proteins based on the extent of smoking. A weak negative correlation was found between protein concentration and DMF-T scores (r = −0.239). Dominant salivary protein bands of 11.6 kDa and 54.5 kDa were found in smokers and 27 kDa, 60 kDa, and 94.5 kDa were found in non-smokers. Conclusion: Different protein bands appeared in smokers and non-smokers. There was a weak correlation between protein concentration, DMF-T scores, and the extent of smoking.
format	article
author	Endang W. Bachtiar Destri S. Gusliana Boy M. Bachtiar
author_facet	Endang W. Bachtiar Destri S. Gusliana Boy M. Bachtiar
author_sort	Endang W. Bachtiar
title	Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
title_short	Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
title_full	Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
title_fullStr	Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
title_full_unstemmed	Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
title_sort	correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d0f4dfe0cf7844d49280d14cae09f640
work_keys_str_mv	AT endangwbachtiar correlationbetweentheextentofsmokingsalivaryproteinprofilesanddentalcariesinyoungadultsmokers AT destrisgusliana correlationbetweentheextentofsmokingsalivaryproteinprofilesanddentalcariesinyoungadultsmokers AT boymbachtiar correlationbetweentheextentofsmokingsalivaryproteinprofilesanddentalcariesinyoungadultsmokers
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Correlation between the extent of smoking, salivary protein profiles, and dental caries in young adult smokers

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