Vive la Persistence: Engineering Human Microbiomes in the 21st Century

ABSTRACT I imagine a future in which children grow up with healthy microbial communities. Engineering human microbiomes might actually be achievable in the near future, as we enter an era of hunting for human-adapted bacterial strains and phages. Furthermore, breath metabolites could allow us to tra...

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Autor principal:	Katrine L. Whiteson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	metabolomics microbiome phage therapy Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d0f58774d26f4829bfe4722f3228b2bf
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spelling	oai:doaj.org-article:d0f58774d26f4829bfe4722f3228b2bf2021-12-02T19:46:20ZVive la Persistence: Engineering Human Microbiomes in the 21st Century10.1128/mSystems.00166-172379-5077https://doaj.org/article/d0f58774d26f4829bfe4722f3228b2bf2018-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00166-17https://doaj.org/toc/2379-5077ABSTRACT I imagine a future in which children grow up with healthy microbial communities. Engineering human microbiomes might actually be achievable in the near future, as we enter an era of hunting for human-adapted bacterial strains and phages. Furthermore, breath metabolites could allow us to track whether a probiotic colonizes persistently or a phage has knocked down a microbe of interest. Recent successes with probiotics, such as bifidobacteria that can break down human milk oligosaccharides, are making a future in which infants are intentionally colonized with health-promoting strains seem less unlikely. Viruses that infect bacteria, bacteriophages, are also important for human health both because of their role in the human microbiome and because of their potential for use in phage therapy. Monitoring the outcome of microbiome-focused interventions with breath volatile sampling is also on the horizon, which could mean real-time tracking of microbial metabolite production. Studies of early life during microbiome assembly, when the potential for effective interventions to reduce disease risk is greatest, are essential.Katrine L. WhitesonAmerican Society for Microbiologyarticlemetabolomicsmicrobiomephage therapyMicrobiologyQR1-502ENmSystems, Vol 3, Iss 2 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics microbiome phage therapy Microbiology QR1-502
spellingShingle	metabolomics microbiome phage therapy Microbiology QR1-502 Katrine L. Whiteson Vive la Persistence: Engineering Human Microbiomes in the 21st Century
description	ABSTRACT I imagine a future in which children grow up with healthy microbial communities. Engineering human microbiomes might actually be achievable in the near future, as we enter an era of hunting for human-adapted bacterial strains and phages. Furthermore, breath metabolites could allow us to track whether a probiotic colonizes persistently or a phage has knocked down a microbe of interest. Recent successes with probiotics, such as bifidobacteria that can break down human milk oligosaccharides, are making a future in which infants are intentionally colonized with health-promoting strains seem less unlikely. Viruses that infect bacteria, bacteriophages, are also important for human health both because of their role in the human microbiome and because of their potential for use in phage therapy. Monitoring the outcome of microbiome-focused interventions with breath volatile sampling is also on the horizon, which could mean real-time tracking of microbial metabolite production. Studies of early life during microbiome assembly, when the potential for effective interventions to reduce disease risk is greatest, are essential.
format	article
author	Katrine L. Whiteson
author_facet	Katrine L. Whiteson
author_sort	Katrine L. Whiteson
title	Vive la Persistence: Engineering Human Microbiomes in the 21st Century
title_short	Vive la Persistence: Engineering Human Microbiomes in the 21st Century
title_full	Vive la Persistence: Engineering Human Microbiomes in the 21st Century
title_fullStr	Vive la Persistence: Engineering Human Microbiomes in the 21st Century
title_full_unstemmed	Vive la Persistence: Engineering Human Microbiomes in the 21st Century
title_sort	vive la persistence: engineering human microbiomes in the 21st century
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/d0f58774d26f4829bfe4722f3228b2bf
work_keys_str_mv	AT katrinelwhiteson vivelapersistenceengineeringhumanmicrobiomesinthe21stcentury
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Vive la Persistence: Engineering Human Microbiomes in the 21st Century

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