Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

Pseudomonas aeruginosa is an opportunistic pathogen that synthesizes and secretes a wide range of virulence factors. P. aeruginosa poses a potential threat to human health worldwide due to its omnipresent nature, robust host accumulation, high virulence, and sig...

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Autores principales:	Maria Sultan, Rekha Arya, Kyeong Kyu Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Pseudomonas aeruginosa</i> virulence two-component system (tcs) biofilm motility pyocyanin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d0f5ae4cd03149128bb203284bca7300
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id	oai:doaj.org-article:d0f5ae4cd03149128bb203284bca7300
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spelling	oai:doaj.org-article:d0f5ae4cd03149128bb203284bca73002021-11-25T17:53:50ZRoles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence10.3390/ijms2222121521422-00671661-6596https://doaj.org/article/d0f5ae4cd03149128bb203284bca73002021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12152https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067<i>Pseudomonas aeruginosa</i> is an opportunistic pathogen that synthesizes and secretes a wide range of virulence factors. <i>P. aeruginosa</i> poses a potential threat to human health worldwide due to its omnipresent nature, robust host accumulation, high virulence, and significant resistance to multiple antibiotics. The pathogenicity of <i>P. aeruginosa</i>, which is associated with acute and chronic infections, is linked with multiple virulence factors and associated secretion systems, such as the ability to form and utilize a biofilm, pili, flagella, alginate, pyocyanin, proteases, and toxins. Two-component systems (TCSs) of <i>P. aeruginosa</i> perform an essential role in controlling virulence factors in response to internal and external stimuli. Therefore, understanding the mechanism of TCSs to perceive and respond to signals from the environment and control the production of virulence factors during infection is essential to understanding the diseases caused by <i>P. aeruginosa</i> infection and further develop new antibiotics to treat this pathogen. This review discusses the important virulence factors of <i>P. aeruginosa</i> and the understanding of their regulation through TCSs by focusing on biofilm, motility, pyocyanin, and cytotoxins.Maria SultanRekha AryaKyeong Kyu KimMDPI AGarticle<i>Pseudomonas aeruginosa</i>virulencetwo-component system (tcs)biofilmmotilitypyocyaninBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12152, p 12152 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Pseudomonas aeruginosa</i> virulence two-component system (tcs) biofilm motility pyocyanin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	<i>Pseudomonas aeruginosa</i> virulence two-component system (tcs) biofilm motility pyocyanin Biology (General) QH301-705.5 Chemistry QD1-999 Maria Sultan Rekha Arya Kyeong Kyu Kim Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
description	<i>Pseudomonas aeruginosa</i> is an opportunistic pathogen that synthesizes and secretes a wide range of virulence factors. <i>P. aeruginosa</i> poses a potential threat to human health worldwide due to its omnipresent nature, robust host accumulation, high virulence, and significant resistance to multiple antibiotics. The pathogenicity of <i>P. aeruginosa</i>, which is associated with acute and chronic infections, is linked with multiple virulence factors and associated secretion systems, such as the ability to form and utilize a biofilm, pili, flagella, alginate, pyocyanin, proteases, and toxins. Two-component systems (TCSs) of <i>P. aeruginosa</i> perform an essential role in controlling virulence factors in response to internal and external stimuli. Therefore, understanding the mechanism of TCSs to perceive and respond to signals from the environment and control the production of virulence factors during infection is essential to understanding the diseases caused by <i>P. aeruginosa</i> infection and further develop new antibiotics to treat this pathogen. This review discusses the important virulence factors of <i>P. aeruginosa</i> and the understanding of their regulation through TCSs by focusing on biofilm, motility, pyocyanin, and cytotoxins.
format	article
author	Maria Sultan Rekha Arya Kyeong Kyu Kim
author_facet	Maria Sultan Rekha Arya Kyeong Kyu Kim
author_sort	Maria Sultan
title	Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
title_short	Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
title_full	Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
title_fullStr	Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
title_full_unstemmed	Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence
title_sort	roles of two-component systems in <i>pseudomonas aeruginosa</i> virulence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d0f5ae4cd03149128bb203284bca7300
work_keys_str_mv	AT mariasultan rolesoftwocomponentsystemsinipseudomonasaeruginosaivirulence AT rekhaarya rolesoftwocomponentsystemsinipseudomonasaeruginosaivirulence AT kyeongkyukim rolesoftwocomponentsystemsinipseudomonasaeruginosaivirulence
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Roles of Two-Component Systems in <i>Pseudomonas aeruginosa</i> Virulence

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