Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review
Thayalini Shanmuganathan,1 Christian Girgis,2 Hooshang Lahooti,1 Bernard Champion,1 Jack R Wall1 1Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, 2Department of Medicine, Westmead Millennium Institute, The University of Sydney, Sydney, NSW...
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Dove Medical Press
2015
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oai:doaj.org-article:d0fb03a38fb8430a83d7e33920eb95062021-12-02T02:00:24ZDoes autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review1177-5483https://doaj.org/article/d0fb03a38fb8430a83d7e33920eb95062015-12-01T00:00:00Zhttps://www.dovepress.com/does-autoimmunity-against-thyroglobulin-play-a-role-in-the-pathogenesi-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Thayalini Shanmuganathan,1 Christian Girgis,2 Hooshang Lahooti,1 Bernard Champion,1 Jack R Wall1 1Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, 2Department of Medicine, Westmead Millennium Institute, The University of Sydney, Sydney, NSW, Australia Abstract: While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves’ hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves’ ophthalmopathy. Keywords: ophthalmopathy, Graves’ disease, thyroglobulin, thyroid peroxidase, TSH receptor, lymphocytes, autoantibodies Shanmuganathan TGirgis CLahooti HChampion BWall JRDove Medical PressarticleophthalmopathyGraves diseasethyroglobulinthyroid peroxidaseTSH receptorlymphocytesautoantibodiesOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss Issue 1, Pp 2271-2276 (2015) |
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DOAJ |
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DOAJ |
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EN |
| topic |
ophthalmopathy Graves disease thyroglobulin thyroid peroxidase TSH receptor lymphocytes autoantibodies Ophthalmology RE1-994 |
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ophthalmopathy Graves disease thyroglobulin thyroid peroxidase TSH receptor lymphocytes autoantibodies Ophthalmology RE1-994 Shanmuganathan T Girgis C Lahooti H Champion B Wall JR Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| description |
Thayalini Shanmuganathan,1 Christian Girgis,2 Hooshang Lahooti,1 Bernard Champion,1 Jack R Wall1 1Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, 2Department of Medicine, Westmead Millennium Institute, The University of Sydney, Sydney, NSW, Australia Abstract: While most authors believe that autoimmunity against the TSH receptor expressed in the orbital connective tissue cells is the main reaction that leads to the development of ophthalmopathy in patients with Graves’ hyperthyroidism, an older hypothesis that deserves fresh consideration is based on the notion that thyroglobulin (Tg) in the thyroid gland passes in a retrograde fashion to the orbit where it is recognized by Tg autoantibodies, leading to inflammation. Here, we review new evidence that supports a role of Tg and propose a new hypothesis based on the notion that Tg is targeted in the orbit leading to a complex cascade of reactions that leads to Graves’ ophthalmopathy. Keywords: ophthalmopathy, Graves’ disease, thyroglobulin, thyroid peroxidase, TSH receptor, lymphocytes, autoantibodies |
| format |
article |
| author |
Shanmuganathan T Girgis C Lahooti H Champion B Wall JR |
| author_facet |
Shanmuganathan T Girgis C Lahooti H Champion B Wall JR |
| author_sort |
Shanmuganathan T |
| title |
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| title_short |
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| title_full |
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| title_fullStr |
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| title_full_unstemmed |
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review |
| title_sort |
does autoimmunity against thyroglobulin play a role in the pathogenesis of graves’ ophthalmopathy: a review |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/d0fb03a38fb8430a83d7e33920eb9506 |
| work_keys_str_mv |
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