INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN

The aim of the review is to analyze literature data about sleep homeostasis and the role of the one of circadian system key elements – melatonin – in the regulation of the sleep-wake cycle in women in menopause. It was shown that the prevalence and structure of sleep disorders depends on the menopau...

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Autores principales:	N. V. Semenova, I. M. Madaeva, L. I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	circadian rhythms melatonin menopause insomnia Science Q
Acceso en línea:	https://doaj.org/article/d0fc4dd7b2e34d23be076cdafce4375a
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spelling	oai:doaj.org-article:d0fc4dd7b2e34d23be076cdafce4375a2021-11-23T06:14:41ZINSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN2541-94202587-959610.29413/ABS.2018-3.5.2https://doaj.org/article/d0fc4dd7b2e34d23be076cdafce4375a2018-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/701https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the review is to analyze literature data about sleep homeostasis and the role of the one of circadian system key elements – melatonin – in the regulation of the sleep-wake cycle in women in menopause. It was shown that the prevalence and structure of sleep disorders depends on the menopausal phase. It was revealed that the melatonin content in the body, determined in various biological media (blood, saliva, urine), depends on age, sex, race, and chronotype. It was shown that morning melatonin can be used as a biological marker for determining the chronotype. Most studies indicated a decrease in melatonin level with aging. Moreover, women have lower melatonin level than men. In case of insomnia, lower melatonin level was found, although the results of the studies are ambiguous. The shift in the peak of hormone secretion in the early morning hours was described in menopausal women. Also, the dependence of melatonin circadian rhythm on the menopausal phase was revealed, which determines different approaches to insomnia therapy. We revealed the association of melatonin secretion circadian rhythms with Clock 3111T/C gene polymorphism in Caucasian patients with insomnia, which allows considering 3111T allele as risky in the formation of melatonin circadian rhythm disturbances in these patients.N. V. SemenovaI. M. MadaevaL. I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlecircadian rhythmsmelatoninmenopauseinsomniaScienceQRUActa Biomedica Scientifica, Vol 3, Iss 5, Pp 16-21 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	circadian rhythms melatonin menopause insomnia Science Q
spellingShingle	circadian rhythms melatonin menopause insomnia Science Q N. V. Semenova I. M. Madaeva L. I. Kolesnikova INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
description	The aim of the review is to analyze literature data about sleep homeostasis and the role of the one of circadian system key elements – melatonin – in the regulation of the sleep-wake cycle in women in menopause. It was shown that the prevalence and structure of sleep disorders depends on the menopausal phase. It was revealed that the melatonin content in the body, determined in various biological media (blood, saliva, urine), depends on age, sex, race, and chronotype. It was shown that morning melatonin can be used as a biological marker for determining the chronotype. Most studies indicated a decrease in melatonin level with aging. Moreover, women have lower melatonin level than men. In case of insomnia, lower melatonin level was found, although the results of the studies are ambiguous. The shift in the peak of hormone secretion in the early morning hours was described in menopausal women. Also, the dependence of melatonin circadian rhythm on the menopausal phase was revealed, which determines different approaches to insomnia therapy. We revealed the association of melatonin secretion circadian rhythms with Clock 3111T/C gene polymorphism in Caucasian patients with insomnia, which allows considering 3111T allele as risky in the formation of melatonin circadian rhythm disturbances in these patients.
format	article
author	N. V. Semenova I. M. Madaeva L. I. Kolesnikova
author_facet	N. V. Semenova I. M. Madaeva L. I. Kolesnikova
author_sort	N. V. Semenova
title	INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
title_short	INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
title_full	INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
title_fullStr	INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
title_full_unstemmed	INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN
title_sort	insomnia and circadian rhythms of melatonin in menopausal women
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/d0fc4dd7b2e34d23be076cdafce4375a
work_keys_str_mv	AT nvsemenova insomniaandcircadianrhythmsofmelatonininmenopausalwomen AT immadaeva insomniaandcircadianrhythmsofmelatonininmenopausalwomen AT likolesnikova insomniaandcircadianrhythmsofmelatonininmenopausalwomen
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INSOMNIA AND CIRCADIAN RHYTHMS OF MELATONIN IN MENOPAUSAL WOMEN

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