Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode

Background: Despite the high reactivity of the platinum electrode, the iodine-coated platinum electrode shows obvious inertness toward adsorption and surface processes. For that, iodine-coated platinum electrodes accommodate themselves to interesting voltammetric applications. Objectives: This stud...

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Autores principales:	Mohammad Amayreh, Wafa Hourani, Mohammed Khair Hourani
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2021
Materias:	ascorbic acid analysis pharmaceutical formulation voltammetric analysis iodine-coated platinum electrode modified platinum electrode Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/d0fdd2c714b14553ae3a65d0fd8b7842
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spelling	oai:doaj.org-article:d0fdd2c714b14553ae3a65d0fd8b78422021-12-02T18:20:59ZVoltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode10.17533/udea.vitae.v28n2a3462280121-40042145-2660https://doaj.org/article/d0fdd2c714b14553ae3a65d0fd8b78422021-06-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/346228https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Background: Despite the high reactivity of the platinum electrode, the iodine-coated platinum electrode shows obvious inertness toward adsorption and surface processes. For that, iodine-coated platinum electrodes accommodate themselves to interesting voltammetric applications. Objectives: This study reports using the modified iodine-coated polycrystalline platinum electrode as a voltammetric sensor for ascorbic acid determination in pharmaceutical formulations. Methods: The developed voltammetric method based on recording cyclic voltammograms of ascorbic acid at iodine-coated electrode The optimized experimental parameters for the determination of ascorbic acid were using 0.1 M KCl as a supporting electrolyte with a scan rate of 50mV/s. Results: The anodic peak related to ascorbic acid oxidation was centered at nearly 0.28V. An excellent and extended linear dependence of the oxidative peak current on the concentration of ascorbic acid was observed in the range 2.84x10-3 - 5.68 mM. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.0 µM and 3.01 µM, respectively, attesting to the method’s sensitivity. The investigation for the effect of potential interference from multivitamin tablet ingredients (vitamins B1, B6, B12, folic acid, citric acid, sucrose, glucose, and zinc) indicated specific selectivity toward ascorbic acid and the absence of any electrochemical response toward these components. Recovery results in the range 98.93±2.78 - 99.98±5.20 for spiked standard ascorbic acid in pharmaceutical formulations further confirmed the potential applicability of the developed method for the determination of ascorbic acid in real samples. Conclusions: The developed method was successfully applied to the analysis of ascorbic acid (vitamin C), and the obtained results were in good agreement with the labeled values; besides, the statistical tests indicated no significant difference at p=0.05 with a 95% confidence level. Mohammad AmayrehWafa HouraniMohammed Khair HouraniUniversidad de Antioquiaarticleascorbic acid analysispharmaceutical formulationvoltammetric analysisiodine-coated platinum electrodemodified platinum electrodeFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 28, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ascorbic acid analysis pharmaceutical formulation voltammetric analysis iodine-coated platinum electrode modified platinum electrode Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	ascorbic acid analysis pharmaceutical formulation voltammetric analysis iodine-coated platinum electrode modified platinum electrode Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Mohammad Amayreh Wafa Hourani Mohammed Khair Hourani Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
description	Background: Despite the high reactivity of the platinum electrode, the iodine-coated platinum electrode shows obvious inertness toward adsorption and surface processes. For that, iodine-coated platinum electrodes accommodate themselves to interesting voltammetric applications. Objectives: This study reports using the modified iodine-coated polycrystalline platinum electrode as a voltammetric sensor for ascorbic acid determination in pharmaceutical formulations. Methods: The developed voltammetric method based on recording cyclic voltammograms of ascorbic acid at iodine-coated electrode The optimized experimental parameters for the determination of ascorbic acid were using 0.1 M KCl as a supporting electrolyte with a scan rate of 50mV/s. Results: The anodic peak related to ascorbic acid oxidation was centered at nearly 0.28V. An excellent and extended linear dependence of the oxidative peak current on the concentration of ascorbic acid was observed in the range 2.84x10-3 - 5.68 mM. The limit of detection (LOD) and limit of quantitation (LOQ) were 1.0 µM and 3.01 µM, respectively, attesting to the method’s sensitivity. The investigation for the effect of potential interference from multivitamin tablet ingredients (vitamins B1, B6, B12, folic acid, citric acid, sucrose, glucose, and zinc) indicated specific selectivity toward ascorbic acid and the absence of any electrochemical response toward these components. Recovery results in the range 98.93±2.78 - 99.98±5.20 for spiked standard ascorbic acid in pharmaceutical formulations further confirmed the potential applicability of the developed method for the determination of ascorbic acid in real samples. Conclusions: The developed method was successfully applied to the analysis of ascorbic acid (vitamin C), and the obtained results were in good agreement with the labeled values; besides, the statistical tests indicated no significant difference at p=0.05 with a 95% confidence level.
format	article
author	Mohammad Amayreh Wafa Hourani Mohammed Khair Hourani
author_facet	Mohammad Amayreh Wafa Hourani Mohammed Khair Hourani
author_sort	Mohammad Amayreh
title	Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
title_short	Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
title_full	Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
title_fullStr	Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
title_full_unstemmed	Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode
title_sort	voltammetric determination of ascorbic acid in pharmaceutical formulations using modified iodine-coated platinum electrode
publisher	Universidad de Antioquia
publishDate	2021
url	https://doaj.org/article/d0fdd2c714b14553ae3a65d0fd8b7842
work_keys_str_mv	AT mohammadamayreh voltammetricdeterminationofascorbicacidinpharmaceuticalformulationsusingmodifiediodinecoatedplatinumelectrode AT wafahourani voltammetricdeterminationofascorbicacidinpharmaceuticalformulationsusingmodifiediodinecoatedplatinumelectrode AT mohammedkhairhourani voltammetricdeterminationofascorbicacidinpharmaceuticalformulationsusingmodifiediodinecoatedplatinumelectrode
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Voltammetric Determination of Ascorbic Acid in Pharmaceutical Formulations Using Modified Iodine-Coated Platinum Electrode

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