Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the pa...

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Autores principales: G. Costa, M. Gildenhard, M. Eldering, R. L. Lindquist, A. E. Hauser, R. Sauerwein, C. Goosmann, V. Brinkmann, P. Carrillo-Bustamante, E. A. Levashina
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d0ff37703f7c4f89aa8c57e9682c2d38
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Sumario:The evolution of within-host malaria virulence has been studied, but the vector’s contribution isn’t well understood. Here, Costa et al. show that non-competitive parasitic resource exploitation within-vector, in particular lipid trafficking, restricts within-host infectivity and virulence of the parasite.