The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines

CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory vi...

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Autores principales:	Zhuoyi Liang, Yi Zhan, Yang Shen, Catherine C. L. Wong, John R. Yates, Florian Plattner, Kwok-On Lai, Nancy Y. Ip
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d0ffb0de24424d838846584b6e6c4411
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spelling	oai:doaj.org-article:d0ffb0de24424d838846584b6e6c44112021-12-02T14:38:54ZThe pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines10.1038/ncomms132822041-1723https://doaj.org/article/d0ffb0de24424d838846584b6e6c44112016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13282https://doaj.org/toc/2041-1723CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition.Zhuoyi LiangYi ZhanYang ShenCatherine C. L. WongJohn R. YatesFlorian PlattnerKwok-On LaiNancy Y. IpNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
description	CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition.
format	article
author	Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip
author_facet	Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip
author_sort	Zhuoyi Liang
title	The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
title_short	The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
title_full	The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
title_fullStr	The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
title_full_unstemmed	The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
title_sort	pseudokinase camkv is required for the activity-dependent maintenance of dendritic spines
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d0ffb0de24424d838846584b6e6c4411
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The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines

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