Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment

Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits,...

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Autores principales:	Qing Ye, Haifeng Chen, Renyuan Liu, Ruomeng Qin, Caimei Luo, Mengchun Li, Yun Xu, Hui Zhao, Feng Bai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	episodic memory executive function mild cognitive impairment functional magnetic resonance imaging hippocampal network medial prefrontal cortex network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d0ffd00caa6e4ce0bb44cde05ffbb499
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spelling	oai:doaj.org-article:d0ffd00caa6e4ce0bb44cde05ffbb4992021-11-17T05:46:23ZLateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment1663-436510.3389/fnagi.2021.756241https://doaj.org/article/d0ffd00caa6e4ce0bb44cde05ffbb4992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.756241/fullhttps://doaj.org/toc/1663-4365Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks.Qing YeQing YeQing YeQing YeHaifeng ChenHaifeng ChenHaifeng ChenHaifeng ChenRenyuan LiuRenyuan LiuRuomeng QinRuomeng QinRuomeng QinRuomeng QinCaimei LuoCaimei LuoCaimei LuoCaimei LuoMengchun LiMengchun LiMengchun LiMengchun LiYun XuYun XuYun XuYun XuHui ZhaoHui ZhaoHui ZhaoHui ZhaoFeng BaiFeng BaiFeng BaiFeng BaiFrontiers Media S.A.articleepisodic memoryexecutive functionmild cognitive impairmentfunctional magnetic resonance imaginghippocampal networkmedial prefrontal cortex networkNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	episodic memory executive function mild cognitive impairment functional magnetic resonance imaging hippocampal network medial prefrontal cortex network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	episodic memory executive function mild cognitive impairment functional magnetic resonance imaging hippocampal network medial prefrontal cortex network Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Qing Ye Qing Ye Qing Ye Qing Ye Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Renyuan Liu Renyuan Liu Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Yun Xu Yun Xu Yun Xu Yun Xu Hui Zhao Hui Zhao Hui Zhao Hui Zhao Feng Bai Feng Bai Feng Bai Feng Bai Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
description	Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks.
format	article
author	Qing Ye Qing Ye Qing Ye Qing Ye Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Renyuan Liu Renyuan Liu Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Yun Xu Yun Xu Yun Xu Yun Xu Hui Zhao Hui Zhao Hui Zhao Hui Zhao Feng Bai Feng Bai Feng Bai Feng Bai
author_facet	Qing Ye Qing Ye Qing Ye Qing Ye Haifeng Chen Haifeng Chen Haifeng Chen Haifeng Chen Renyuan Liu Renyuan Liu Ruomeng Qin Ruomeng Qin Ruomeng Qin Ruomeng Qin Caimei Luo Caimei Luo Caimei Luo Caimei Luo Mengchun Li Mengchun Li Mengchun Li Mengchun Li Yun Xu Yun Xu Yun Xu Yun Xu Hui Zhao Hui Zhao Hui Zhao Hui Zhao Feng Bai Feng Bai Feng Bai Feng Bai
author_sort	Qing Ye
title	Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_short	Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_full	Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_fullStr	Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_full_unstemmed	Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
title_sort	lateralized contributions of medial prefrontal cortex network to episodic memory deficits in subjects with amnestic mild cognitive impairment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d0ffd00caa6e4ce0bb44cde05ffbb499
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Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment

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