Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit

Abstract Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs rem...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Myung Jin Song, Seok Kim, Dachung Boo, Changhyun Park, Sooyoung Yoo, Ho Il Yoon, Young-Jae Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d10080e1c21442db92543f31c8dd7309
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d10080e1c21442db92543f31c8dd7309
record_format	dspace
spelling	oai:doaj.org-article:d10080e1c21442db92543f31c8dd73092021-12-02T17:23:46ZComparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit10.1038/s41598-021-98069-72045-2322https://doaj.org/article/d10080e1c21442db92543f31c8dd73092021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98069-7https://doaj.org/toc/2045-2322Abstract Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear. In this retrospective, observational, comparative cohort study, PPIs and H2RAs for stress ulcer prophylaxis in critically ill patients were compared using a common data model. After propensity matching, 935 patients from each treatment group (PPI or H2RA) were selected. The PPI group had a significantly higher 90-day mortality than the H2RA group (relative risk: 1.28; P = 0.01). However, no significant inter-group differences in the risk of clinically important gastrointestinal bleeding were observed. Moreover, there were no significant differences between the groups concerning the risk of pneumonia or Clostridioides difficile infection, which are known potential adverse events related to these drugs. Subgroup analysis of patients with high disease severity were consistent with those of the total propensity score-matched population. These findings do not support the current recommendations, which prefer PPIs for gastrointestinal bleeding prophylaxis in the intensive care unit.Myung Jin SongSeok KimDachung BooChanghyun ParkSooyoung YooHo Il YoonYoung-Jae ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Myung Jin Song Seok Kim Dachung Boo Changhyun Park Sooyoung Yoo Ho Il Yoon Young-Jae Cho Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
description	Abstract Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear. In this retrospective, observational, comparative cohort study, PPIs and H2RAs for stress ulcer prophylaxis in critically ill patients were compared using a common data model. After propensity matching, 935 patients from each treatment group (PPI or H2RA) were selected. The PPI group had a significantly higher 90-day mortality than the H2RA group (relative risk: 1.28; P = 0.01). However, no significant inter-group differences in the risk of clinically important gastrointestinal bleeding were observed. Moreover, there were no significant differences between the groups concerning the risk of pneumonia or Clostridioides difficile infection, which are known potential adverse events related to these drugs. Subgroup analysis of patients with high disease severity were consistent with those of the total propensity score-matched population. These findings do not support the current recommendations, which prefer PPIs for gastrointestinal bleeding prophylaxis in the intensive care unit.
format	article
author	Myung Jin Song Seok Kim Dachung Boo Changhyun Park Sooyoung Yoo Ho Il Yoon Young-Jae Cho
author_facet	Myung Jin Song Seok Kim Dachung Boo Changhyun Park Sooyoung Yoo Ho Il Yoon Young-Jae Cho
author_sort	Myung Jin Song
title	Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
title_short	Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
title_full	Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
title_fullStr	Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
title_full_unstemmed	Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
title_sort	comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d10080e1c21442db92543f31c8dd7309
work_keys_str_mv	AT myungjinsong comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT seokkim comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT dachungboo comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT changhyunpark comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT sooyoungyoo comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT hoilyoon comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit AT youngjaecho comparisonofprotonpumpinhibitorsandhistamine2receptorantagonistsforstressulcerprophylaxisintheintensivecareunit
_version_	1718380996527652864

Comparison of proton pump inhibitors and histamine 2 receptor antagonists for stress ulcer prophylaxis in the intensive care unit

Ejemplares similares