Beetroot Extracts as Haematopoietic Agents on Rats

Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on...

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Autores principales:	Ni Putu Ermi Hikmawanti, Lusi Putri Dwita, Dinitia Az Zahra
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	beetroots, extract, haematopoietic Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d1022198fd654b05ae5b5a2fdf8150d3
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spelling	oai:doaj.org-article:d1022198fd654b05ae5b5a2fdf8150d32021-11-15T06:08:46ZBeetroot Extracts as Haematopoietic Agents on Rats2338-94272338-948610.22146/ijp.1132https://doaj.org/article/d1022198fd654b05ae5b5a2fdf8150d32021-05-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1132https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent.Ni Putu Ermi HikmawantiLusi Putri DwitaDinitia Az ZahraUniversitas Gadjah Madaarticlebeetroots, extract, haematopoieticPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 175-178 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	beetroots, extract, haematopoietic Pharmacy and materia medica RS1-441
spellingShingle	beetroots, extract, haematopoietic Pharmacy and materia medica RS1-441 Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra Beetroot Extracts as Haematopoietic Agents on Rats
description	Introduction: Beetroot (Beta vulgaris L.) contains flavonoid compounds that play a role in the haematopoietic process. It is known that methanol extract of beetroot has benefits in the process of haematopoiesis in normal white rats. Aims: To evaluate the beetroots extracts as hematopoietic agents on male rats. Methods: Beetroots dried powder was divided into two parts. One part was macerated separately with dichloromethane and 70% ethanol, while the other part is added with citric acid and washed with water to remove alkaloids and then extracted with 70% ethanol. The study used 24 rats which were divided into four groups. Each group consisted of 6 rats, namely the normal group, dichloromethane extract group, ethanolic extract group, and free alkaloids-ethanolic extract group. Each extract was given at a dose of 200 mg.Kg-1 for 21 days. Analyzed blood parameters are erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets. The data obtained consisted of the number of cells analyzed using one-way ANOVA then obtained by the Tukey test. Results: This study showed a significant increase in the number of erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets in rats that were given each extract compared to the normal group (p <0.05). The ethanolic extract of beetroot can increase erythrocytes, haemoglobin, MCV, MCH, MCHC, leukocytes, and platelets by 41.49%, 24.95%, 14.92%, 33.54%, 27.19%, 59.40%, and 35.37%, respectively. Conclusions: The ethanolic extract of beetroot has the potential as a good natural haematopoietic agent.
format	article
author	Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra
author_facet	Ni Putu Ermi Hikmawanti Lusi Putri Dwita Dinitia Az Zahra
author_sort	Ni Putu Ermi Hikmawanti
title	Beetroot Extracts as Haematopoietic Agents on Rats
title_short	Beetroot Extracts as Haematopoietic Agents on Rats
title_full	Beetroot Extracts as Haematopoietic Agents on Rats
title_fullStr	Beetroot Extracts as Haematopoietic Agents on Rats
title_full_unstemmed	Beetroot Extracts as Haematopoietic Agents on Rats
title_sort	beetroot extracts as haematopoietic agents on rats
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/d1022198fd654b05ae5b5a2fdf8150d3
work_keys_str_mv	AT niputuermihikmawanti beetrootextractsashaematopoieticagentsonrats AT lusiputridwita beetrootextractsashaematopoieticagentsonrats AT dinitiaazzahra beetrootextractsashaematopoieticagentsonrats
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Beetroot Extracts as Haematopoietic Agents on Rats

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