A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand
Abstract Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30–40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic p...
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Nature Portfolio
2017
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oai:doaj.org-article:d10280ed37014a01a7f55d92431460832021-12-02T11:41:00ZA comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand10.1038/s41598-017-04957-22045-2322https://doaj.org/article/d10280ed37014a01a7f55d92431460832017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04957-2https://doaj.org/toc/2045-2322Abstract Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30–40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-α3.7, -α4.2, --SEA and --THAI) and/or non-deletional alpha-thalassaemia (αCS and αPS) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha+(-α3.7, -α4.2, αCS and αPS) and alpha°-thalassaemia (--SEA and --THAI) allele frequencies (with 95% Confidence Interval) were the highest in the Sino-Tibetan group [0.13 (0.08–0.18)] and the Tai-Kadai group [0.03 (0.02–0.05)], respectively. With regards to ethnicity, the varying allele frequency of α+ and α°-thalassaemia amongst a variety of ethnic groups was observed. The highest α+-thalassaemia allele frequency was found in the Paluang [0.21 (0.10–0.37)] while α°-thalassaemia allele frequency was the highest in the Yuan [0.04 (0.01–0.10)]. These detailed results of alpha thalassaemia allele frequency and genetic diversity amongst the northern Thai ethnic groups demonstrate the need for ethnicity based thalassaemia prevention programs.Mattapong KulaphisitJatupol KampuansaiKamonlak LeecharoenkiatMethi WathikthinnakonDaoroong KangwanpongThongperm MunkongdeeSaovaros SvastiSuthat FucharoenDuncan R. SmithPathrapol LithanatudomNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q Mattapong Kulaphisit Jatupol Kampuansai Kamonlak Leecharoenkiat Methi Wathikthinnakon Daoroong Kangwanpong Thongperm Munkongdee Saovaros Svasti Suthat Fucharoen Duncan R. Smith Pathrapol Lithanatudom A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| description |
Abstract Alpha (α)-thalassaemia is one of the most prevalent hereditary blood disorders, commonly affecting Southeast Asian people, with the highest incidence (30–40%) being seen in northern Thailand. However, this high incidence was estimated without consideration of the variations between ethnic populations and the geographical location of the populations. To address this issue, a total of 688 samples from 13 different northern Thai ethnic groups (30 villages) categorized into three linguistic groups were genotyped for deletional alpha-thalassaemia (-α3.7, -α4.2, --SEA and --THAI) and/or non-deletional alpha-thalassaemia (αCS and αPS) via multiplex gap-PCR and dot-blot hybridization, respectively. Alpha+(-α3.7, -α4.2, αCS and αPS) and alpha°-thalassaemia (--SEA and --THAI) allele frequencies (with 95% Confidence Interval) were the highest in the Sino-Tibetan group [0.13 (0.08–0.18)] and the Tai-Kadai group [0.03 (0.02–0.05)], respectively. With regards to ethnicity, the varying allele frequency of α+ and α°-thalassaemia amongst a variety of ethnic groups was observed. The highest α+-thalassaemia allele frequency was found in the Paluang [0.21 (0.10–0.37)] while α°-thalassaemia allele frequency was the highest in the Yuan [0.04 (0.01–0.10)]. These detailed results of alpha thalassaemia allele frequency and genetic diversity amongst the northern Thai ethnic groups demonstrate the need for ethnicity based thalassaemia prevention programs. |
| format |
article |
| author |
Mattapong Kulaphisit Jatupol Kampuansai Kamonlak Leecharoenkiat Methi Wathikthinnakon Daoroong Kangwanpong Thongperm Munkongdee Saovaros Svasti Suthat Fucharoen Duncan R. Smith Pathrapol Lithanatudom |
| author_facet |
Mattapong Kulaphisit Jatupol Kampuansai Kamonlak Leecharoenkiat Methi Wathikthinnakon Daoroong Kangwanpong Thongperm Munkongdee Saovaros Svasti Suthat Fucharoen Duncan R. Smith Pathrapol Lithanatudom |
| author_sort |
Mattapong Kulaphisit |
| title |
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| title_short |
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| title_full |
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| title_fullStr |
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| title_full_unstemmed |
A comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern Thailand |
| title_sort |
comprehensive ethnic-based analysis of alpha thalassaemia allelle frequency in northern thailand |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/d10280ed37014a01a7f55d9243146083 |
| work_keys_str_mv |
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