In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

Fei Tong, Rongkui Chai, Haiying Jiang, Bo DongDepartment of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, People’s Republic of China Background: The objective of this study was to survey the therapeutic func...

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Autores principales:	Tong F, Chai R, Jiang H, Dong B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	PBLG-PEG-PBLG curcumin diabetic cardiomyopathy CaSR CSE Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d102a5b5c0374ee9bbc1c9474564cb93
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spelling	oai:doaj.org-article:d102a5b5c0374ee9bbc1c9474564cb932021-12-02T05:18:26ZIn vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles1178-2013https://doaj.org/article/d102a5b5c0374ee9bbc1c9474564cb932018-04-01T00:00:00Zhttps://www.dovepress.com/in-vitrovivo-drug-release-and-anti-diabetic-cardiomyopathy-properties--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fei Tong, Rongkui Chai, Haiying Jiang, Bo DongDepartment of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, People’s Republic of China Background: The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S). Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. The blood and myocardiums were collected, the level of serum H2S was observed, and the [Ca2+]i content was measured in myocardial cells, and hematoxylin-eosin, CaSR, CSE, and calmodulin (CaM) expression were detected. Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect. Conclusion: PBLG-PEG-PBLG could improve water-solubility and bioactivity of curcumin and curcumin/PBLG-PEG-PBLG significantly alleviated diabetic cardiomyopathy.Keywords: PBLG-PEG-PBLG, curcumin, diabetic cardiomyopathy, CaSR, CSETong FChai RJiang HDong BDove Medical PressarticlePBLG-PEG-PBLGcurcumindiabetic cardiomyopathyCaSRCSEMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1945-1962 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	PBLG-PEG-PBLG curcumin diabetic cardiomyopathy CaSR CSE Medicine (General) R5-920
spellingShingle	PBLG-PEG-PBLG curcumin diabetic cardiomyopathy CaSR CSE Medicine (General) R5-920 Tong F Chai R Jiang H Dong B In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
description	Fei Tong, Rongkui Chai, Haiying Jiang, Bo DongDepartment of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, People’s Republic of China Background: The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S). Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. The blood and myocardiums were collected, the level of serum H2S was observed, and the [Ca2+]i content was measured in myocardial cells, and hematoxylin-eosin, CaSR, CSE, and calmodulin (CaM) expression were detected. Results: Both curcumin and curcumin/P pretreatment alleviated pathological morphological damage of myocardium, increased H2S and [Ca2+]i levels, and upregulated the expression of CaSR, CSE, and CaM as compared to DCM group, while curcumin/P remarkably augmented this effect. Conclusion: PBLG-PEG-PBLG could improve water-solubility and bioactivity of curcumin and curcumin/PBLG-PEG-PBLG significantly alleviated diabetic cardiomyopathy.Keywords: PBLG-PEG-PBLG, curcumin, diabetic cardiomyopathy, CaSR, CSE
format	article
author	Tong F Chai R Jiang H Dong B
author_facet	Tong F Chai R Jiang H Dong B
author_sort	Tong F
title	In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
title_short	In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
title_full	In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
title_fullStr	In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
title_full_unstemmed	In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles
title_sort	in vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/pblg-peg-pblg nanoparticles
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/d102a5b5c0374ee9bbc1c9474564cb93
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In vitro/vivo drug release and anti-diabetic cardiomyopathy properties of curcumin/PBLG-PEG-PBLG nanoparticles

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