Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure

Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Vasily Kashtalap, Olga BarbarashFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: The most common cause of myocardial infarction (MI) is stenotic atheroscle...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gruzdeva O, Uchasova E, Dyleva Y, Belik E, Kashtalap V, Barbarash O
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d105145bf7f34584a8889f8dec5ab222
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d105145bf7f34584a8889f8dec5ab222
record_format	dspace
spelling	oai:doaj.org-article:d105145bf7f34584a8889f8dec5ab2222021-12-02T05:29:07ZRelationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure1178-7007https://doaj.org/article/d105145bf7f34584a8889f8dec5ab2222013-02-01T00:00:00Zhttp://www.dovepress.com/relationship-between-free-fatty-acids-insulin-resistance-markers-and-o-a12242https://doaj.org/toc/1178-7007Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Vasily Kashtalap, Olga BarbarashFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI is the leader in mortality and morbidity. Recent studies have been trying to find new biochemical markers that could predict the evolution of clinical complications; among those markers, free fatty acids (FFA) and oxidative modification of low-density lipoproteins (oxidized LDL) have a special place.Materials and methods: Seventy-nine ST-elevation MI patients were enrolled. The first group included MI patients without the signs of acute heart failure (Killip class I) while MI patients with Killip classes II&ndash;IV made up the second group. Thirty-three individuals with no cardiovascular disease were the controls. The lipid profile, serum oxidized LDL, and their antibodies, C-peptide and insulin were measured at days 1 and 12. The level of insulin resistance was assessed with the quantitative insulin sensitivity check index (QUICKI).Results: MI patients had atherogenic dyslipidemia; however, the Killip II&ndash;IV group had the most pronounced and prolonged increase in FFA, oxidized LDL, and their antibodies. Additionally, positive correlations between FFA levels and creatine kinase activity (12 days, R = 0.301; P = 0.001) and negative correlations between the QUICKI index and FFA levels (R = &ndash;0.46; P = 0.0013 and R = &ndash;0.5; P = 0.01) were observed in the both groups.Conclusion: The development of MI complications is accompanied by a significant increase in FFA levels, which not only demonstrate myocardial injury, but also take part in development of insulin resistance. Measuring FFA levels can have a great prognostic potential for risk stratification of both acute and recurrent coronary events and choice of treatment strategy.Keywords: myocardial infarction, free fatty acids, insulin resistanceGruzdeva OUchasova EDyleva YBelik EKashtalap VBarbarash ODove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 103-111 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Gruzdeva O Uchasova E Dyleva Y Belik E Kashtalap V Barbarash O Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
description	Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Vasily Kashtalap, Olga BarbarashFederal State Budgetary Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, RussiaBackground: The most common cause of myocardial infarction (MI) is stenotic atherosclerotic lesions in subepicardial coronary arteries. Artery disease progression induces clinical signs and symptoms, among which MI is the leader in mortality and morbidity. Recent studies have been trying to find new biochemical markers that could predict the evolution of clinical complications; among those markers, free fatty acids (FFA) and oxidative modification of low-density lipoproteins (oxidized LDL) have a special place.Materials and methods: Seventy-nine ST-elevation MI patients were enrolled. The first group included MI patients without the signs of acute heart failure (Killip class I) while MI patients with Killip classes II&ndash;IV made up the second group. Thirty-three individuals with no cardiovascular disease were the controls. The lipid profile, serum oxidized LDL, and their antibodies, C-peptide and insulin were measured at days 1 and 12. The level of insulin resistance was assessed with the quantitative insulin sensitivity check index (QUICKI).Results: MI patients had atherogenic dyslipidemia; however, the Killip II&ndash;IV group had the most pronounced and prolonged increase in FFA, oxidized LDL, and their antibodies. Additionally, positive correlations between FFA levels and creatine kinase activity (12 days, R = 0.301; P = 0.001) and negative correlations between the QUICKI index and FFA levels (R = &ndash;0.46; P = 0.0013 and R = &ndash;0.5; P = 0.01) were observed in the both groups.Conclusion: The development of MI complications is accompanied by a significant increase in FFA levels, which not only demonstrate myocardial injury, but also take part in development of insulin resistance. Measuring FFA levels can have a great prognostic potential for risk stratification of both acute and recurrent coronary events and choice of treatment strategy.Keywords: myocardial infarction, free fatty acids, insulin resistance
format	article
author	Gruzdeva O Uchasova E Dyleva Y Belik E Kashtalap V Barbarash O
author_facet	Gruzdeva O Uchasova E Dyleva Y Belik E Kashtalap V Barbarash O
author_sort	Gruzdeva O
title	Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
title_short	Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
title_full	Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
title_fullStr	Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
title_full_unstemmed	Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
title_sort	relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d105145bf7f34584a8889f8dec5ab222
work_keys_str_mv	AT gruzdevao relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure AT uchasovae relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure AT dylevay relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure AT belike relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure AT kashtalapv relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure AT barbarasho relationshipbetweenfreefattyacidsinsulinresistancemarkersandoxidizedlipoproteinsinmyocardialinfarctionandacuteleftventricularfailure
_version_	1718400379213840384

Relationship between free fatty acids, insulin resistance markers, and oxidized lipoproteins in myocardial infarction and acute left ventricular failure

Ejemplares similares