Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery
The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Sciendo
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d1057b6778fb434ab7d4e65ea6393e0e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d1057b6778fb434ab7d4e65ea6393e0e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d1057b6778fb434ab7d4e65ea6393e0e2021-11-17T21:27:52ZCardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery1820-744810.2478/acve-2014-0044https://doaj.org/article/d1057b6778fb434ab7d4e65ea6393e0e2014-12-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0044https://doaj.org/toc/1820-7448The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine and diazepam). Cardiorespiratory variables, acid-base indices, quality of sedation, induction, intubation and recovery were recorded throughout the experiment. Significant changes were observed for the pO2 level, which was increased in the AMDgroup from 90 min. (*P< 0.05) to 120 min. (**P< 0.01) of anesthesia. This can be explained by a reduction of the administration rate of propofol/fentanyl TIVA and oxygenation initiated due to excessively deep anesthesia detected by an anesthetsiologist, leading to improved ventilation and increased pO2. The pCO2 (*P < 0.05) reached more preferable values during the first 30 min. and pH (**P< 0.01) was significantly improved within the first 60 min. in the AXD-group thanks to less depressant effects of xylazine. Within the first 30 min. of anesthesia a significant heart rate difference between the groups was accompanied with significantly higher BP (hypertension) in the AXD-group (10 min. ***P< 0.001, 30 min. **P< 0.01). This points to the possibility of atropine application only in the case of a tendency to bradycardia followed by hypotension. It can be concluded that xylazine is a better option for the premedication of a propofol/ fentanyl TIVA in dogs undergoing a prolonged surgical intervention, in spite of the fact that lower sedation scores were attained. We have detected significantly less adverse cardio-respiratory and hemodynamic effects of xylazine, and a shorter recovery time when compared to medetomidineTomáš LiptákIgor CapíkValent LedeckýOskar NagyMária KuricováCsilla TóthováAladár MaďariJana FarbákováVladimír PetrovičSlavomír HorňákSciendoarticleintravenous anesthesialong-term anesthesiadogfentanylpropofolVeterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 4, Pp 466-476 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
intravenous anesthesia long-term anesthesia dog fentanyl propofol Veterinary medicine SF600-1100 |
| spellingShingle |
intravenous anesthesia long-term anesthesia dog fentanyl propofol Veterinary medicine SF600-1100 Tomáš Lipták Igor Capík Valent Ledecký Oskar Nagy Mária Kuricová Csilla Tóthová Aladár Maďari Jana Farbáková Vladimír Petrovič Slavomír Horňák Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| description |
The aim of this study was to compare the effects of different premedication protocols followed by a propofol/fentanyl TIVA on cardio-respiratory and hemodynamic changes in twenty-four dogs randomly divided into two groups (AMD-group: medetomidine, atropine and diazepam; AXD-group: xylazine, atropine and diazepam). Cardiorespiratory variables, acid-base indices, quality of sedation, induction, intubation and recovery were recorded throughout the experiment. Significant changes were observed for the pO2 level, which was increased in the AMDgroup from 90 min. (*P< 0.05) to 120 min. (**P< 0.01) of anesthesia. This can be explained by a reduction of the administration rate of propofol/fentanyl TIVA and oxygenation initiated due to excessively deep anesthesia detected by an anesthetsiologist, leading to improved ventilation and increased pO2. The pCO2 (*P < 0.05) reached more preferable values during the first 30 min. and pH (**P< 0.01) was significantly improved within the first 60 min. in the AXD-group thanks to less depressant effects of xylazine. Within the first 30 min. of anesthesia a significant heart rate difference between the groups was accompanied with significantly higher BP (hypertension) in the AXD-group (10 min. ***P< 0.001, 30 min. **P< 0.01). This points to the possibility of atropine application only in the case of a tendency to bradycardia followed by hypotension. It can be concluded that xylazine is a better option for the premedication of a propofol/ fentanyl TIVA in dogs undergoing a prolonged surgical intervention, in spite of the fact that lower sedation scores were attained. We have detected significantly less adverse cardio-respiratory and hemodynamic effects of xylazine, and a shorter recovery time when compared to medetomidine |
| format |
article |
| author |
Tomáš Lipták Igor Capík Valent Ledecký Oskar Nagy Mária Kuricová Csilla Tóthová Aladár Maďari Jana Farbáková Vladimír Petrovič Slavomír Horňák |
| author_facet |
Tomáš Lipták Igor Capík Valent Ledecký Oskar Nagy Mária Kuricová Csilla Tóthová Aladár Maďari Jana Farbáková Vladimír Petrovič Slavomír Horňák |
| author_sort |
Tomáš Lipták |
| title |
Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| title_short |
Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| title_full |
Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| title_fullStr |
Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| title_full_unstemmed |
Cardiorespiratory and Hemodynamic Effects of Medetomidine or Xylazine with Atropine and Diazepam Premedication for Total Intravenous Anesthesia Induced and Maintained with Propofol/Fentanyl in Dogs Undergoing Surgery |
| title_sort |
cardiorespiratory and hemodynamic effects of medetomidine or xylazine with atropine and diazepam premedication for total intravenous anesthesia induced and maintained with propofol/fentanyl in dogs undergoing surgery |
| publisher |
Sciendo |
| publishDate |
2014 |
| url |
https://doaj.org/article/d1057b6778fb434ab7d4e65ea6393e0e |
| work_keys_str_mv |
AT tomasliptak cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT igorcapik cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT valentledecky cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT oskarnagy cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT mariakuricova cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT csillatothova cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT aladarmadari cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT janafarbakova cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT vladimirpetrovic cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery AT slavomirhornak cardiorespiratoryandhemodynamiceffectsofmedetomidineorxylazinewithatropineanddiazepampremedicationfortotalintravenousanesthesiainducedandmaintainedwithpropofolfentanylindogsundergoingsurgery |
| _version_ |
1718425318769819648 |