DNA Repair in Haploid Context

DNA repair is a well-covered topic as alteration of genetic integrity underlies many pathological conditions and important transgenerational consequences. Surprisingly, the ploidy status is rarely considered although the presence of homologous chromosomes dramatically impacts the repair capacities o...

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Autores principales:	Loïs Mourrain, Guylain Boissonneault
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA repair haploid diploid gametes <i>Saccharomyces cerevisiae</i> <i>Schizosaccharomyces pombe</i> Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d105a58f8ba34b05ae353cdadd770b9e
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id	oai:doaj.org-article:d105a58f8ba34b05ae353cdadd770b9e
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spelling	oai:doaj.org-article:d105a58f8ba34b05ae353cdadd770b9e2021-11-25T17:56:28ZDNA Repair in Haploid Context10.3390/ijms2222124181422-00671661-6596https://doaj.org/article/d105a58f8ba34b05ae353cdadd770b9e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12418https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067DNA repair is a well-covered topic as alteration of genetic integrity underlies many pathological conditions and important transgenerational consequences. Surprisingly, the ploidy status is rarely considered although the presence of homologous chromosomes dramatically impacts the repair capacities of cells. This is especially important for the haploid gametes as they must transfer genetic information to the offspring. An understanding of the different mechanisms monitoring genetic integrity in this context is, therefore, essential as differences in repair pathways exist that differentiate the gamete’s role in transgenerational inheritance. Hence, the oocyte must have the most reliable repair capacity while sperm, produced in large numbers and from many differentiation steps, are expected to carry de novo variations. This review describes the main DNA repair pathways with a special emphasis on ploidy. Differences between <i>Saccharomyces cerevisiae</i> and <i>Schizosaccharomyces pombe</i> are especially useful to this aim as they can maintain a diploid and haploid life cycle respectively.Loïs MourrainGuylain BoissonneaultMDPI AGarticleDNA repairhaploiddiploidgametes<i>Saccharomyces cerevisiae</i><i>Schizosaccharomyces pombe</i>Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12418, p 12418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA repair haploid diploid gametes <i>Saccharomyces cerevisiae</i> <i>Schizosaccharomyces pombe</i> Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	DNA repair haploid diploid gametes <i>Saccharomyces cerevisiae</i> <i>Schizosaccharomyces pombe</i> Biology (General) QH301-705.5 Chemistry QD1-999 Loïs Mourrain Guylain Boissonneault DNA Repair in Haploid Context
description	DNA repair is a well-covered topic as alteration of genetic integrity underlies many pathological conditions and important transgenerational consequences. Surprisingly, the ploidy status is rarely considered although the presence of homologous chromosomes dramatically impacts the repair capacities of cells. This is especially important for the haploid gametes as they must transfer genetic information to the offspring. An understanding of the different mechanisms monitoring genetic integrity in this context is, therefore, essential as differences in repair pathways exist that differentiate the gamete’s role in transgenerational inheritance. Hence, the oocyte must have the most reliable repair capacity while sperm, produced in large numbers and from many differentiation steps, are expected to carry de novo variations. This review describes the main DNA repair pathways with a special emphasis on ploidy. Differences between <i>Saccharomyces cerevisiae</i> and <i>Schizosaccharomyces pombe</i> are especially useful to this aim as they can maintain a diploid and haploid life cycle respectively.
format	article
author	Loïs Mourrain Guylain Boissonneault
author_facet	Loïs Mourrain Guylain Boissonneault
author_sort	Loïs Mourrain
title	DNA Repair in Haploid Context
title_short	DNA Repair in Haploid Context
title_full	DNA Repair in Haploid Context
title_fullStr	DNA Repair in Haploid Context
title_full_unstemmed	DNA Repair in Haploid Context
title_sort	dna repair in haploid context
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d105a58f8ba34b05ae353cdadd770b9e
work_keys_str_mv	AT loismourrain dnarepairinhaploidcontext AT guylainboissonneault dnarepairinhaploidcontext
_version_	1718411832857722880

DNA Repair in Haploid Context

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