Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Abstract Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3). No effective FGFR3-targeted therapies for ACH are currently available. By drug repositioning strategies, we identified that mecloz...

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Autores principales: Masaki Matsushita, Ryusaku Esaki, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/d105b8f11c35482fbfa7a96465102627
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