Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex

Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtIICl4 2− from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtIICl2(NH3)2] ([*Pt]cisplatin) from [*Pt]PtIICl4 2−. [*Pt]PtIICl4 2− was prepared as a synthetic precursor of n.c.a. *Pt com...

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Autores principales:	Honoka Obata, Katsuyuki Minegishi, Kotaro Nagatsu, Mikako Ogawa, Ming-Rong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d10f18828228444fa0a80f935dffe1f7
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spelling	oai:doaj.org-article:d10f18828228444fa0a80f935dffe1f72021-12-02T14:26:16ZSynthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex10.1038/s41598-021-87576-22045-2322https://doaj.org/article/d10f18828228444fa0a80f935dffe1f72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87576-2https://doaj.org/toc/2045-2322Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtIICl4 2− from an Ir target material, and then synthesized n.c.a. [Pt]cis-[PtIICl2(NH3)2] ([Pt]cisplatin) from [Pt]PtIICl4 2−. [Pt]PtIICl4 2− was prepared as a synthetic precursor of n.c.a. Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrIVCl6 2− with ascorbic acid. The ligand-substitution reaction of Cl with NH3 was promoted by treating n.c.a. [Pt]PtIICl4 2− with excess NH3 and heating the reaction mixture, and n.c.a. [Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99 + % at the end of synthesis (EOS).Honoka ObataKatsuyuki MinegishiKotaro NagatsuMikako OgawaMing-Rong ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Honoka Obata Katsuyuki Minegishi Kotaro Nagatsu Mikako Ogawa Ming-Rong Zhang Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
description	Abstract We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtIICl4 2− from an Ir target material, and then synthesized n.c.a. [Pt]cis-[PtIICl2(NH3)2] ([Pt]cisplatin) from [Pt]PtIICl4 2−. [Pt]PtIICl4 2− was prepared as a synthetic precursor of n.c.a. Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrIVCl6 2− with ascorbic acid. The ligand-substitution reaction of Cl with NH3 was promoted by treating n.c.a. [Pt]PtIICl4 2− with excess NH3 and heating the reaction mixture, and n.c.a. [Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99 + % at the end of synthesis (EOS).
format	article
author	Honoka Obata Katsuyuki Minegishi Kotaro Nagatsu Mikako Ogawa Ming-Rong Zhang
author_facet	Honoka Obata Katsuyuki Minegishi Kotaro Nagatsu Mikako Ogawa Ming-Rong Zhang
author_sort	Honoka Obata
title	Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
title_short	Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
title_full	Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
title_fullStr	Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
title_full_unstemmed	Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex
title_sort	synthesis of no-carrier-added [188, 189, 191pt]cisplatin from a cyclotron produced 188, 189, 191ptcl4 2− complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d10f18828228444fa0a80f935dffe1f7
work_keys_str_mv	AT honokaobata synthesisofnocarrieradded188189191ptcisplatinfromacyclotronproduced188189191ptcl42complex AT katsuyukiminegishi synthesisofnocarrieradded188189191ptcisplatinfromacyclotronproduced188189191ptcl42complex AT kotaronagatsu synthesisofnocarrieradded188189191ptcisplatinfromacyclotronproduced188189191ptcl42complex AT mikakoogawa synthesisofnocarrieradded188189191ptcisplatinfromacyclotronproduced188189191ptcl42complex AT mingrongzhang synthesisofnocarrieradded188189191ptcisplatinfromacyclotronproduced188189191ptcl42complex
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Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl4 2− complex

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