Portable and Error-Free DNA-Based Data Storage

Abstract DNA-based data storage is an emerging nonvolatile memory technology of potentially unprecedented density, durability, and replication efficiency. The basic system implementation steps include synthesizing DNA strings that contain user information and subsequently retrieving them via high-th...

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Autores principales:	S. M. Hossein Tabatabaei Yazdi, Ryan Gabrys, Olgica Milenkovic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d111e87e141a47d3a81df1ef74f30297
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spelling	oai:doaj.org-article:d111e87e141a47d3a81df1ef74f302972021-12-02T15:05:01ZPortable and Error-Free DNA-Based Data Storage10.1038/s41598-017-05188-12045-2322https://doaj.org/article/d111e87e141a47d3a81df1ef74f302972017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05188-1https://doaj.org/toc/2045-2322Abstract DNA-based data storage is an emerging nonvolatile memory technology of potentially unprecedented density, durability, and replication efficiency. The basic system implementation steps include synthesizing DNA strings that contain user information and subsequently retrieving them via high-throughput sequencing technologies. Existing architectures enable reading and writing but do not offer random-access and error-free data recovery from low-cost, portable devices, which is crucial for making the storage technology competitive with classical recorders. Here we show for the first time that a portable, random-access platform may be implemented in practice using nanopore sequencers. The novelty of our approach is to design an integrated processing pipeline that encodes data to avoid costly synthesis and sequencing errors, enables random access through addressing, and leverages efficient portable sequencing via new iterative alignment and deletion error-correcting codes. Our work represents the only known random access DNA-based data storage system that uses error-prone nanopore sequencers, while still producing error-free readouts with the highest reported information rate. As such, it represents a crucial step towards practical employment of DNA molecules as storage media.S. M. Hossein Tabatabaei YazdiRyan GabrysOlgica MilenkovicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. M. Hossein Tabatabaei Yazdi Ryan Gabrys Olgica Milenkovic Portable and Error-Free DNA-Based Data Storage
description	Abstract DNA-based data storage is an emerging nonvolatile memory technology of potentially unprecedented density, durability, and replication efficiency. The basic system implementation steps include synthesizing DNA strings that contain user information and subsequently retrieving them via high-throughput sequencing technologies. Existing architectures enable reading and writing but do not offer random-access and error-free data recovery from low-cost, portable devices, which is crucial for making the storage technology competitive with classical recorders. Here we show for the first time that a portable, random-access platform may be implemented in practice using nanopore sequencers. The novelty of our approach is to design an integrated processing pipeline that encodes data to avoid costly synthesis and sequencing errors, enables random access through addressing, and leverages efficient portable sequencing via new iterative alignment and deletion error-correcting codes. Our work represents the only known random access DNA-based data storage system that uses error-prone nanopore sequencers, while still producing error-free readouts with the highest reported information rate. As such, it represents a crucial step towards practical employment of DNA molecules as storage media.
format	article
author	S. M. Hossein Tabatabaei Yazdi Ryan Gabrys Olgica Milenkovic
author_facet	S. M. Hossein Tabatabaei Yazdi Ryan Gabrys Olgica Milenkovic
author_sort	S. M. Hossein Tabatabaei Yazdi
title	Portable and Error-Free DNA-Based Data Storage
title_short	Portable and Error-Free DNA-Based Data Storage
title_full	Portable and Error-Free DNA-Based Data Storage
title_fullStr	Portable and Error-Free DNA-Based Data Storage
title_full_unstemmed	Portable and Error-Free DNA-Based Data Storage
title_sort	portable and error-free dna-based data storage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d111e87e141a47d3a81df1ef74f30297
work_keys_str_mv	AT smhosseintabatabaeiyazdi portableanderrorfreednabaseddatastorage AT ryangabrys portableanderrorfreednabaseddatastorage AT olgicamilenkovic portableanderrorfreednabaseddatastorage
_version_	1718388984168579072

Portable and Error-Free DNA-Based Data Storage

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