Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers

Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitroand improves survival in...

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Autores principales:	Jin-Ah Kim, Ying Tan, Xian Wang, Xixi Cao, Jamunarani Veeraraghavan, Yulong Liang, Dean P. Edwards, Shixia Huang, Xuewen Pan, Kaiyi Li, Rachel Schiff, Xiao-Song Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d11277306f8740c7bc492ad6c983bd7f
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spelling	oai:doaj.org-article:d11277306f8740c7bc492ad6c983bd7f2021-12-02T16:49:40ZComprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers10.1038/ncomms129912041-1723https://doaj.org/article/d11277306f8740c7bc492ad6c983bd7f2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12991https://doaj.org/toc/2041-1723Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitroand improves survival in mice.Jin-Ah KimYing TanXian WangXixi CaoJamunarani VeeraraghavanYulong LiangDean P. EdwardsShixia HuangXuewen PanKaiyi LiRachel SchiffXiao-Song WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jin-Ah Kim Ying Tan Xian Wang Xixi Cao Jamunarani Veeraraghavan Yulong Liang Dean P. Edwards Shixia Huang Xuewen Pan Kaiyi Li Rachel Schiff Xiao-Song Wang Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
description	Luminal B oestrogen receptor positive breast cancers are generally aggressive tumors with poor outcomes. Here, the authors show that the kinase TLK2 is amplified and overexpressed in these tumors and correlates with reduced survival, TLK2 inhibition induces apoptosis in vitroand improves survival in mice.
format	article
author	Jin-Ah Kim Ying Tan Xian Wang Xixi Cao Jamunarani Veeraraghavan Yulong Liang Dean P. Edwards Shixia Huang Xuewen Pan Kaiyi Li Rachel Schiff Xiao-Song Wang
author_facet	Jin-Ah Kim Ying Tan Xian Wang Xixi Cao Jamunarani Veeraraghavan Yulong Liang Dean P. Edwards Shixia Huang Xuewen Pan Kaiyi Li Rachel Schiff Xiao-Song Wang
author_sort	Jin-Ah Kim
title	Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
title_short	Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
title_full	Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
title_fullStr	Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
title_full_unstemmed	Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
title_sort	comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d11277306f8740c7bc492ad6c983bd7f
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Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers

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