FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

FOXM1 is a known transcription factor which promotes cell proliferation in cancer cells. Here, the authors show that FOXM1 is required for the maintenance of quiescence and self-renewal of leukemia stem cells in MLL-AF9-rearranged acute myeloid leukemia patient and mouse models.

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Autores principales: Yue Sheng, Chunjie Yu, Yin Liu, Chao Hu, Rui Ma, Xinyan Lu, Peng Ji, Jianjun Chen, Benjamin Mizukawa, Yong Huang, Jonathan D. Licht, Zhijian Qian
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d11424310ec44b5ca95d292b8b733cac
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spelling oai:doaj.org-article:d11424310ec44b5ca95d292b8b733cac2021-12-02T15:37:19ZFOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML10.1038/s41467-020-14590-92041-1723https://doaj.org/article/d11424310ec44b5ca95d292b8b733cac2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14590-9https://doaj.org/toc/2041-1723FOXM1 is a known transcription factor which promotes cell proliferation in cancer cells. Here, the authors show that FOXM1 is required for the maintenance of quiescence and self-renewal of leukemia stem cells in MLL-AF9-rearranged acute myeloid leukemia patient and mouse models.Yue ShengChunjie YuYin LiuChao HuRui MaXinyan LuPeng JiJianjun ChenBenjamin MizukawaYong HuangJonathan D. LichtZhijian QianNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yue Sheng
Chunjie Yu
Yin Liu
Chao Hu
Rui Ma
Xinyan Lu
Peng Ji
Jianjun Chen
Benjamin Mizukawa
Yong Huang
Jonathan D. Licht
Zhijian Qian
FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
description FOXM1 is a known transcription factor which promotes cell proliferation in cancer cells. Here, the authors show that FOXM1 is required for the maintenance of quiescence and self-renewal of leukemia stem cells in MLL-AF9-rearranged acute myeloid leukemia patient and mouse models.
format article
author Yue Sheng
Chunjie Yu
Yin Liu
Chao Hu
Rui Ma
Xinyan Lu
Peng Ji
Jianjun Chen
Benjamin Mizukawa
Yong Huang
Jonathan D. Licht
Zhijian Qian
author_facet Yue Sheng
Chunjie Yu
Yin Liu
Chao Hu
Rui Ma
Xinyan Lu
Peng Ji
Jianjun Chen
Benjamin Mizukawa
Yong Huang
Jonathan D. Licht
Zhijian Qian
author_sort Yue Sheng
title FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
title_short FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
title_full FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
title_fullStr FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
title_full_unstemmed FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML
title_sort foxm1 regulates leukemia stem cell quiescence and survival in mll-rearranged aml
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d11424310ec44b5ca95d292b8b733cac
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