MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway

MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway

Abstract Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for calcific nodule formation in CAVD pa...

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Bibliographic Details
Main Authors: Rongjian Xu, Min Zhao, Yun Yang, Zhuo Huang, Chunying Shi, Xianglin Hou, Yannan Zhao, Bing Chen, Zhifeng Xiao, Jianzhou Liu, Qi Miao, Jianwu Dai
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/d1162d7bcc4b49c592bdfd9f316410a6
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