COVID-19 in pregnant and non-pregnant women of early reproductive age

Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in pregnant and non-pregnant patients of early reproductive age who have no known risk factors and premorbid background. Materials and methods. The study included 163 pregnant women in the third trimest...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tatiana E. Belokrinitskaya, Nataly I. Frolova, Konstantin G. Shapovalov, Kristina A. Kolmakova, Ludmila I. Anohova, Alexandra V. Avrachenkova, Svetlana V. Prejmak, Alexey V. Grigor'ev, Tatiana Y. Filyova, Albina N. Gorbunova, Dmitry A. Dunaev, Kristina S. Serbina
Formato:	article
Lenguaje:	RU
Publicado:	IP Berlin A.V. 2021
Materias:	pregnancy reproductive period coronavirus infection covid-19 clinic pneumonia risk factors Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/d1163fdb25e9473cafae3219d538a64d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d1163fdb25e9473cafae3219d538a64d
record_format	dspace
spelling	oai:doaj.org-article:d1163fdb25e9473cafae3219d538a64d2021-12-02T19:22:24ZCOVID-19 in pregnant and non-pregnant women of early reproductive age2079-56962079-583110.26442/20795696.2021.3.200882https://doaj.org/article/d1163fdb25e9473cafae3219d538a64d2021-08-01T00:00:00Zhttps://gynecology.orscience.ru/2079-5831/article/viewFile/76154/56748https://doaj.org/toc/2079-5696https://doaj.org/toc/2079-5831Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in pregnant and non-pregnant patients of early reproductive age who have no known risk factors and premorbid background. Materials and methods. The study included 163 pregnant women in the third trimester of gestation, 100 non-pregnant women with laboratory-confirmed SARS-CoV-2 infection and 100 pregnant women who did not get sick. Patients of all groups were comparable in age (1835 years), social status, parity, body mass index, had no known risk factors for COVID-19; those who got sick were treated simultaneously. Results. Statistically significant associations were revealed between COVID-19 infection in the pregnant and iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat ethnicity, and smoking. Pregnant women with COVID-19 were more likely to have no symptoms (23.3% vs 5%; p0.001) or had a mild course of the disease (58.9% vs 24%; p0.001). In non-pregnant patients, the course of infection was more often moderate (61% vs 14.7%; p0.001) or severe (10% vs 3.1%; p=0.038). Clinical manifestations of new coronavirus infection (NCV) in pregnant women were dominated by anosmia (87.7% vs 40%; p0.001), drowsiness (68.7% vs 17%; p0.001), dyspnea, even with a mild lung lesion (68.1% vs 19%; p0.001), headache (41.7% vs 24%; p=0.006), arthralgia (29.4% vs 16%; p=0.021), while fever above 38 C (7.4% vs 28%; p0.001) and cough (38.7% vs 61%; p0.001) were much less common. With computed tomography, pneumonia in pregnant women was diagnosed several times less often (21.4% vs 87.4%; p0.001). In the non-pregnant group, there was one death (1% vs 0%; p=0.201) associated with late hospitalization for severe NCI with grade 4 pulmonary involvement as shown on computed tomography. Conclusion. Confounders of COVID-19 in pregnant women who have no known risk factors in the third trimester of gestation are iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat subpopulation, and smoking. In pregnant women, the main clinical symptoms of SARS-CoV-2 infection, with the exception of loss of smell, were nonspecific and characteristic of the physiological course of late gestation: drowsiness, dyspnea, joint pain. The predominance of mild or asymptomatic forms of infection, the lower incidence of pneumonia, and the absence of deaths in pregnant women suggests a more favorable course of COVID-19 NCI.Tatiana E. BelokrinitskayaNataly I. FrolovaKonstantin G. ShapovalovKristina A. KolmakovaLudmila I. AnohovaAlexandra V. AvrachenkovaSvetlana V. PrejmakAlexey V. Grigor'evTatiana Y. FilyovaAlbina N. GorbunovaDmitry A. DunaevKristina S. SerbinaIP Berlin A.V. articlepregnancyreproductive periodcoronavirus infectioncovid-19clinicpneumoniarisk factorsGynecology and obstetricsRG1-991RUГинекология, Vol 23, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	pregnancy reproductive period coronavirus infection covid-19 clinic pneumonia risk factors Gynecology and obstetrics RG1-991
spellingShingle	pregnancy reproductive period coronavirus infection covid-19 clinic pneumonia risk factors Gynecology and obstetrics RG1-991 Tatiana E. Belokrinitskaya Nataly I. Frolova Konstantin G. Shapovalov Kristina A. Kolmakova Ludmila I. Anohova Alexandra V. Avrachenkova Svetlana V. Prejmak Alexey V. Grigor'ev Tatiana Y. Filyova Albina N. Gorbunova Dmitry A. Dunaev Kristina S. Serbina COVID-19 in pregnant and non-pregnant women of early reproductive age
description	Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in pregnant and non-pregnant patients of early reproductive age who have no known risk factors and premorbid background. Materials and methods. The study included 163 pregnant women in the third trimester of gestation, 100 non-pregnant women with laboratory-confirmed SARS-CoV-2 infection and 100 pregnant women who did not get sick. Patients of all groups were comparable in age (1835 years), social status, parity, body mass index, had no known risk factors for COVID-19; those who got sick were treated simultaneously. Results. Statistically significant associations were revealed between COVID-19 infection in the pregnant and iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat ethnicity, and smoking. Pregnant women with COVID-19 were more likely to have no symptoms (23.3% vs 5%; p0.001) or had a mild course of the disease (58.9% vs 24%; p0.001). In non-pregnant patients, the course of infection was more often moderate (61% vs 14.7%; p0.001) or severe (10% vs 3.1%; p=0.038). Clinical manifestations of new coronavirus infection (NCV) in pregnant women were dominated by anosmia (87.7% vs 40%; p0.001), drowsiness (68.7% vs 17%; p0.001), dyspnea, even with a mild lung lesion (68.1% vs 19%; p0.001), headache (41.7% vs 24%; p=0.006), arthralgia (29.4% vs 16%; p=0.021), while fever above 38 C (7.4% vs 28%; p0.001) and cough (38.7% vs 61%; p0.001) were much less common. With computed tomography, pneumonia in pregnant women was diagnosed several times less often (21.4% vs 87.4%; p0.001). In the non-pregnant group, there was one death (1% vs 0%; p=0.201) associated with late hospitalization for severe NCI with grade 4 pulmonary involvement as shown on computed tomography. Conclusion. Confounders of COVID-19 in pregnant women who have no known risk factors in the third trimester of gestation are iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat subpopulation, and smoking. In pregnant women, the main clinical symptoms of SARS-CoV-2 infection, with the exception of loss of smell, were nonspecific and characteristic of the physiological course of late gestation: drowsiness, dyspnea, joint pain. The predominance of mild or asymptomatic forms of infection, the lower incidence of pneumonia, and the absence of deaths in pregnant women suggests a more favorable course of COVID-19 NCI.
format	article
author	Tatiana E. Belokrinitskaya Nataly I. Frolova Konstantin G. Shapovalov Kristina A. Kolmakova Ludmila I. Anohova Alexandra V. Avrachenkova Svetlana V. Prejmak Alexey V. Grigor'ev Tatiana Y. Filyova Albina N. Gorbunova Dmitry A. Dunaev Kristina S. Serbina
author_facet	Tatiana E. Belokrinitskaya Nataly I. Frolova Konstantin G. Shapovalov Kristina A. Kolmakova Ludmila I. Anohova Alexandra V. Avrachenkova Svetlana V. Prejmak Alexey V. Grigor'ev Tatiana Y. Filyova Albina N. Gorbunova Dmitry A. Dunaev Kristina S. Serbina
author_sort	Tatiana E. Belokrinitskaya
title	COVID-19 in pregnant and non-pregnant women of early reproductive age
title_short	COVID-19 in pregnant and non-pregnant women of early reproductive age
title_full	COVID-19 in pregnant and non-pregnant women of early reproductive age
title_fullStr	COVID-19 in pregnant and non-pregnant women of early reproductive age
title_full_unstemmed	COVID-19 in pregnant and non-pregnant women of early reproductive age
title_sort	covid-19 in pregnant and non-pregnant women of early reproductive age
publisher	IP Berlin A.V.
publishDate	2021
url	https://doaj.org/article/d1163fdb25e9473cafae3219d538a64d
work_keys_str_mv	AT tatianaebelokrinitskaya covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT natalyifrolova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT konstantingshapovalov covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT kristinaakolmakova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT ludmilaianohova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT alexandravavrachenkova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT svetlanavprejmak covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT alexeyvgrigorev covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT tatianayfilyova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT albinangorbunova covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT dmitryadunaev covid19inpregnantandnonpregnantwomenofearlyreproductiveage AT kristinasserbina covid19inpregnantandnonpregnantwomenofearlyreproductiveage
_version_	1718376764698263552

COVID-19 in pregnant and non-pregnant women of early reproductive age

Ejemplares similares