Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L<sup>−</sup>C7L<sup>−</sup> Mutant

ABSTRACT RNA interference (RNAi) screens intended to identify host factors that restrict virus replication may fail if the virus already counteracts host defense mechanisms. To overcome this limitation, we are investigating the use of viral host range mutants that exhibit impaired replication in non...

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Autores principales: Gilad Sivan, Pinar Ormanoglu, Eugen C. Buehler, Scott E. Martin, Bernard Moss
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://doaj.org/article/d117b90181ff40aa80cce6d71aa5e247
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