The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3...

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Autores principales:	Junqiao Jia, Eva Absmeier, Nicole Holton, Agnieszka J. Pietrzyk-Brzezinska, Philipp Hackert, Katherine E. Bohnsack, Markus T. Bohnsack, Markus C. Wahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d118f2503a854806ab453466797e9c86
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spelling	oai:doaj.org-article:d118f2503a854806ab453466797e9c862021-12-02T14:42:14ZThe interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations10.1038/s41467-020-19221-x2041-1723https://doaj.org/article/d118f2503a854806ab453466797e9c862020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19221-xhttps://doaj.org/toc/2041-1723The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3, determine the complex crystal structure and further show that cancer-related mutations at the interface between both proteins reduce ASCC2–ASCC3 affinity.Junqiao JiaEva AbsmeierNicole HoltonAgnieszka J. Pietrzyk-BrzezinskaPhilipp HackertKatherine E. BohnsackMarkus T. BohnsackMarkus C. WahlNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Junqiao Jia Eva Absmeier Nicole Holton Agnieszka J. Pietrzyk-Brzezinska Philipp Hackert Katherine E. Bohnsack Markus T. Bohnsack Markus C. Wahl The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
description	The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway. Here, the authors identify a minimal stable complex of the two ASCC subunits ASCC2 and ASCC3, determine the complex crystal structure and further show that cancer-related mutations at the interface between both proteins reduce ASCC2–ASCC3 affinity.
format	article
author	Junqiao Jia Eva Absmeier Nicole Holton Agnieszka J. Pietrzyk-Brzezinska Philipp Hackert Katherine E. Bohnsack Markus T. Bohnsack Markus C. Wahl
author_facet	Junqiao Jia Eva Absmeier Nicole Holton Agnieszka J. Pietrzyk-Brzezinska Philipp Hackert Katherine E. Bohnsack Markus T. Bohnsack Markus C. Wahl
author_sort	Junqiao Jia
title	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
title_short	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
title_full	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
title_fullStr	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
title_full_unstemmed	The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
title_sort	interaction of dna repair factors ascc2 and ascc3 is affected by somatic cancer mutations
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d118f2503a854806ab453466797e9c86
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The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations

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