Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.

Wilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 5...

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Autores principales:	Lesleyann Hawthorn, John K Cowell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d11fa2db912d413b9b015bf47e00e1ce
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spelling	oai:doaj.org-article:d11fa2db912d413b9b015bf47e00e1ce2021-11-18T06:55:19ZAnalysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.1932-620310.1371/journal.pone.0018941https://doaj.org/article/d11fa2db912d413b9b015bf47e00e1ce2011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21544195/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Wilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 56 Wilms tumors using high resolution oligonucleotide arrays at a average resolution of ~12 Kb. Consistent deletions were seen on chromosomes 1p, 4q, 7p, 9q, 11p, 11q, 14q, 16q, and 21q. High frequency gains were seen for 1q and lower frequency gains were seen on 7q and chromosomes 8, 12 and 18. The high resolution provided by the SNP mapping arrays has defined minimal regions of deletion for many of these LOH events. Analysis of CNAs by tumor stage show relatively stable karyotypes in stage 1 tumors and more complex aCGH profiles in tumors from stages 3-5.Lesleyann HawthornJohn K CowellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18941 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lesleyann Hawthorn John K Cowell Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
description	Wilms tumor (WT) has been a model to study kidney embryogenesis and tumorigenesis and, although associated with hereditary, cancer predisposition syndromes, the majority of tumors occur sporadically. To analyze genetic changes in WT we have defined copy number changes and loss of heterozygosity in 56 Wilms tumors using high resolution oligonucleotide arrays at a average resolution of ~12 Kb. Consistent deletions were seen on chromosomes 1p, 4q, 7p, 9q, 11p, 11q, 14q, 16q, and 21q. High frequency gains were seen for 1q and lower frequency gains were seen on 7q and chromosomes 8, 12 and 18. The high resolution provided by the SNP mapping arrays has defined minimal regions of deletion for many of these LOH events. Analysis of CNAs by tumor stage show relatively stable karyotypes in stage 1 tumors and more complex aCGH profiles in tumors from stages 3-5.
format	article
author	Lesleyann Hawthorn John K Cowell
author_facet	Lesleyann Hawthorn John K Cowell
author_sort	Lesleyann Hawthorn
title	Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
title_short	Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
title_full	Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
title_fullStr	Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
title_full_unstemmed	Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.
title_sort	analysis of wilms tumors using snp mapping array-based comparative genomic hybridization.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/d11fa2db912d413b9b015bf47e00e1ce
work_keys_str_mv	AT lesleyannhawthorn analysisofwilmstumorsusingsnpmappingarraybasedcomparativegenomichybridization AT johnkcowell analysisofwilmstumorsusingsnpmappingarraybasedcomparativegenomichybridization
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Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization.

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