Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.

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Autores principales:	Paul F. McKay, Kai Hu, Anna K. Blakney, Karnyart Samnuan, Jonathan C. Brown, Rebecca Penn, Jie Zhou, Clément R. Bouton, Paul Rogers, Krunal Polra, Paulo J. C. Lin, Christopher Barbosa, Ying K. Tam, Wendy S. Barclay, Robin J. Shattock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
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spelling	oai:doaj.org-article:d121c83855b64dc7847d5eded42ee84e2021-12-02T15:23:19ZSelf-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice10.1038/s41467-020-17409-92041-1723https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17409-9https://doaj.org/toc/2041-1723Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.Paul F. McKayKai HuAnna K. BlakneyKarnyart SamnuanJonathan C. BrownRebecca PennJie ZhouClément R. BoutonPaul RogersKrunal PolraPaulo J. C. LinChristopher BarbosaYing K. TamWendy S. BarclayRobin J. ShattockNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul F. McKay Kai Hu Anna K. Blakney Karnyart Samnuan Jonathan C. Brown Rebecca Penn Jie Zhou Clément R. Bouton Paul Rogers Krunal Polra Paulo J. C. Lin Christopher Barbosa Ying K. Tam Wendy S. Barclay Robin J. Shattock Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
description	Here, the authors develop a self-amplifying RNA encoding the SARS-CoV-2 spike protein encapsulated within a lipid nanoparticle as a vaccine candidate and show induction of neutralization antibody titers in mice that are comparable to titers in convalescent sera of patients.
format	article
author	Paul F. McKay Kai Hu Anna K. Blakney Karnyart Samnuan Jonathan C. Brown Rebecca Penn Jie Zhou Clément R. Bouton Paul Rogers Krunal Polra Paulo J. C. Lin Christopher Barbosa Ying K. Tam Wendy S. Barclay Robin J. Shattock
author_facet	Paul F. McKay Kai Hu Anna K. Blakney Karnyart Samnuan Jonathan C. Brown Rebecca Penn Jie Zhou Clément R. Bouton Paul Rogers Krunal Polra Paulo J. C. Lin Christopher Barbosa Ying K. Tam Wendy S. Barclay Robin J. Shattock
author_sort	Paul F. McKay
title	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
title_short	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
title_full	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
title_fullStr	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
title_full_unstemmed	Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
title_sort	self-amplifying rna sars-cov-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d121c83855b64dc7847d5eded42ee84e
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Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

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