Plasticity of the Influenza Virus H5 HA Protein

The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huihui Kong, David F. Burke, Tiago Jose da Silva Lopes, Kosuke Takada, Masaki Imai, Gongxun Zhong, Masato Hatta, Shufang Fan, Shiho Chiba, Derek Smith, Gabriele Neumann, Yoshihiro Kawaoka
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d123052a7a014ca3a864735ba255a0d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d123052a7a014ca3a864735ba255a0d2
record_format	dspace
spelling	oai:doaj.org-article:d123052a7a014ca3a864735ba255a0d22021-11-03T18:15:38ZPlasticity of the Influenza Virus H5 HA Protein2161-21292150-751110.1128/mBio.03324-20https://doaj.org/article/d123052a7a014ca3a864735ba255a0d22021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03324-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can therefore accommodate many mutations in regions that affect antigenicity. The substantial plasticity of H5 HA may facilitate the emergence of novel antigenic variants.Huihui KongDavid F. BurkeTiago Jose da Silva LopesKosuke TakadaMasaki ImaiGongxun ZhongMasato HattaShufang FanShiho ChibaDerek SmithGabriele NeumannYoshihiro KawaokaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Huihui Kong David F. Burke Tiago Jose da Silva Lopes Kosuke Takada Masaki Imai Gongxun Zhong Masato Hatta Shufang Fan Shiho Chiba Derek Smith Gabriele Neumann Yoshihiro Kawaoka Plasticity of the Influenza Virus H5 HA Protein
description	The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can therefore accommodate many mutations in regions that affect antigenicity. The substantial plasticity of H5 HA may facilitate the emergence of novel antigenic variants.
format	article
author	Huihui Kong David F. Burke Tiago Jose da Silva Lopes Kosuke Takada Masaki Imai Gongxun Zhong Masato Hatta Shufang Fan Shiho Chiba Derek Smith Gabriele Neumann Yoshihiro Kawaoka
author_facet	Huihui Kong David F. Burke Tiago Jose da Silva Lopes Kosuke Takada Masaki Imai Gongxun Zhong Masato Hatta Shufang Fan Shiho Chiba Derek Smith Gabriele Neumann Yoshihiro Kawaoka
author_sort	Huihui Kong
title	Plasticity of the Influenza Virus H5 HA Protein
title_short	Plasticity of the Influenza Virus H5 HA Protein
title_full	Plasticity of the Influenza Virus H5 HA Protein
title_fullStr	Plasticity of the Influenza Virus H5 HA Protein
title_full_unstemmed	Plasticity of the Influenza Virus H5 HA Protein
title_sort	plasticity of the influenza virus h5 ha protein
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/d123052a7a014ca3a864735ba255a0d2
work_keys_str_mv	AT huihuikong plasticityoftheinfluenzavirush5haprotein AT davidfburke plasticityoftheinfluenzavirush5haprotein AT tiagojosedasilvalopes plasticityoftheinfluenzavirush5haprotein AT kosuketakada plasticityoftheinfluenzavirush5haprotein AT masakiimai plasticityoftheinfluenzavirush5haprotein AT gongxunzhong plasticityoftheinfluenzavirush5haprotein AT masatohatta plasticityoftheinfluenzavirush5haprotein AT shufangfan plasticityoftheinfluenzavirush5haprotein AT shihochiba plasticityoftheinfluenzavirush5haprotein AT dereksmith plasticityoftheinfluenzavirush5haprotein AT gabrieleneumann plasticityoftheinfluenzavirush5haprotein AT yoshihirokawaoka plasticityoftheinfluenzavirush5haprotein
_version_	1718445485156466688

Plasticity of the Influenza Virus H5 HA Protein

Ejemplares similares