Plasticity of the Influenza Virus H5 HA Protein

Plasticity of the Influenza Virus H5 HA Protein

The HA protein of influenza A viruses is the major viral antigen. In this study, we simultaneously introduced mutations at 17 amino acid positions of an H5 HA expected to affect antigenicity. Viruses with ≥13 amino acid changes in HA were viable, and some had altered antigenic properties. H5 HA can...

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Autores principales: Huihui Kong, David F. Burke, Tiago Jose da Silva Lopes, Kosuke Takada, Masaki Imai, Gongxun Zhong, Masato Hatta, Shufang Fan, Shiho Chiba, Derek Smith, Gabriele Neumann, Yoshihiro Kawaoka
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/d123052a7a014ca3a864735ba255a0d2
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